IL-1R antagonist Recombinant Protein

Recombinant human IL-1RA protein with molecular weight 22 kDa.
IL1 receptor antagonist (IL1RN) is a protein that binds to IL1 receptors (IL1R1) and inhibits the binding of IL1-alpha and IL1-beta (IL1B). It specifically inhibited IL1 bioactivity on T cells and endothelial cells in vitro and was a potent inhibitor of IL1-induced corticosterone production in vivo. High concentrations of glucose induce beta cell production of IL-1beta, leading to impaired beta cell function and apoptosis in human pancreatic islets. IL-1 receptor antagonist (IL-1Ra) is a naturally occurring antagonist of IL-1beta and protects cultured human islets from glucotoxicity. Therefore, the balance of IL-1beta and IL-1Ra may play a crucial role in the pathogenesis of diabetes. And the expression of IL-1Ra in the human beta cell, providing localized protection against leptin- and glucose-induced islet IL-1beta.

1. Carter, D. B., Deibel, M. R., Jr., Dunn, C. J., Tomich, C.-S. C., Laborde, A. L., Slightom, J. L., Berger, A. E., Bienkowski, M. J., Sun, F. F., McEwan, R. N., Harris, P. K. W., Yem, A. W., Waszak, G. A., Chosay, J. G., Sieu, L. C., Hardee, M. M., Zurcher-Neely, H. A., Reardon, I. M., Heinrikson, R. L., Truesdell, S. E., Shelly, J. A., Eessalu, T. E., Taylor, B. M., Tracey, D. E. Purification, cloning, expression and biological characterization of an interleukin-1 receptor antagonist protein. Nature 344: 633-638, 1990. 2. Maedler, K., Sergeev, P., Ehses, J. A., Mathe, Z., Bosco, D., Berney, T., Dayer, J.-M., Reinecke, M., Halban, P. A., Donath, M. Y. Leptin modulates beta-cell expression of IL-1 receptor antagonist and release of IL-1-beta in human islets. Proc. Nat. Acad. Sci. 101: 8138-8143, 2004.

Small volumes of IL-1R antagonist recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355591 is a recombinant protein targeting IL-1R antagonist. Also known as IL-1R antagonist Protein (Active). Host: E Coli.