G-CSF Recombinant Protein

Name: G-CSF Recombinant Protein; Research Grade; MyBioSource
Brand: MyBioSource
SKU: MBS355593
Price: 280 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS355593

Recombinant human full length G-CSF protein.Granulocyte colony-stimulating factor (G-CSF), also known as colony-stimulating factor 3 (CSF 3), is a glycoprotein, growth factor and cytokine produced by a number of different tissues to stimulate the bone marrow… More details

$280 / 0.01 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

G-CSF, Recombinant Protein

Full Product Name

G-CSF Protein (Active)

Product Gene Name

G-CSF recombinant protein

Host

E Coli

Form/Format

Lyophilized

Preparation and Storage

Ship at 4 degree C. Upon receipt, aliquot and store at -20 degree C or -80 degree C for long term. Avoid repeated freeze and thaw cycles

Molecular Weight

22,293 Da

Chromosome Location

Chromosome: 17; NC_000017.10 (38171614..38174066). Location: 17q11.2-q12

OMIM

138970

3D Structure

ModBase 3D Structure for P09919

Dimers

< 1% by SDS-PAGE

Endotoxin Level

< 0.1 ng/ug (1 EU/ug) by LAL test

Reconstitution

Reconstitute with sterile 18MΩ-cm H2O.

Storage Buffer

Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.

Applications Tested/Suitable for G-CSF recombinant protein

HPLC

Product References and Citations for G-CSF recombinant protein

1. Nagata S, Tsuchiya M, Asano S, Kaziro Y, Yamazaki T, Yamamoto O, Hirata Y, Kubota N, Oheda M, Nomura H (1986). "Molecular cloning and expression of cDNA for human granulocyte colony-stimulating factor". Nature 319 (6052): 415-8. 2. Thomas J, Liu F, Link DC (May 2002). "Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor". Curr. Opin. Hematol. 9 (3): 183-9.

Other Notes

Small volumes of G-CSF recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for G-CSF purchase

MBS355593 is a recombinant protein targeting G-CSF. Also known as G-CSF Protein (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for G-CSF. It may not necessarily be applicable to this product.

NCBI GI #

297660573

NCBI GeneID

1440

NCBI Accession #

ADI49832.1

UniProt Primary Accession #

P09919

UniProt Secondary Accession #

A8MXR7

UniProt Related Accession #

P09919

NCBI Official Full Name

granulocyte colony-stimulating factor

NCBI Official Synonym Full Names

colony stimulating factor 3 (granulocyte)

NCBI Official Symbol

CSF3

NCBI Official Synonym Symbols

GCSF; CSF3OS; C17orf33

UniProt Protein Name

Granulocyte colony-stimulating factor

UniProt Synonym Protein Names

Pluripoietin

Protein Family

Granulocyte colony-stimulating factor receptor

UniProt Gene Name

CSF3

UniProt Synonym Gene Names

C17orf33; GCSF; G-CSF

UniProt Entry Name

CSF3_HUMAN

NCBI Protein Information

granulocyte colony-stimulating factor; filgrastim; lenograstim; pluripoietin

NCBI Summary for G-CSF

The protein encoded by this gene is a cytokine that controls the production, differentiation, and function of granulocytes. The active protein is found extracellularly. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, May 2010]

UniProt Comments for G-CSF

Function: Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.

Subunit structure: Monomer.

Subcellular location: Secreted.

Post-translational modification: O-glycan consists of Gal-GalNAc disaccharide which can be modified with up to two sialic acid residues (done in recombinantly expressed G-CSF from CHO cells).

Pharmaceutical use: Available under the names Neupogen or Granulokine (Amgen/Roche) and Granocyte (Rhone-Poulenc). Used to treat neutropenia (a disorder characterized by an extremely low number of neutrophils in blood).

Sequence similarities: Belongs to the IL-6 superfamily.

Caution: Ref.7 misquotes the gene name as "CSF1".

Research Articles on G-CSF

1. HNF1A gene was associated with C-reactive protein, and the region including PSMD3 and CSF3 genes was associated with white blood cell count.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with G-CSF recombinant protein

Reference Product	PubMed Publications
CSF2 recombinant protein	>15 publications with G-CSF and CSF2
CSF3R recombinant protein	>11 publications with G-CSF and CSF3R
MMP9 recombinant protein	>5 publications with G-CSF and MMP9
IL10 recombinant protein	>5 publications with G-CSF and IL10
CXCL12 recombinant protein	>3 publications with G-CSF and CXCL12
STAT3 recombinant protein	>2 publications with G-CSF and STAT3
SELL recombinant protein	>1 publications with G-CSF and SELL
CXCR4 recombinant protein	>1 publications with G-CSF and CXCR4

Pathways associated with G-CSF recombinant protein

Products by Pathway	Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokine-cytokine Receptor Interaction Pathway antibodies	Cytokine-cytokine Receptor Interaction Pathway Diagram
Cytokines And Inflammatory Response Pathway antibodies	Cytokines And Inflammatory Response Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Hematopoietic Cell Lineage Pathway antibodies	Hematopoietic Cell Lineage Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Jak-STAT Signaling Pathway antibodies	Jak-STAT Signaling Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
Malaria Pathway antibodies	Malaria Pathway Diagram
PI3K-Akt Signaling Pathway antibodies	PI3K-Akt Signaling Pathway Diagram

Diseases associated with G-CSF recombinant protein

Disease Name	Pubmed Publications
Disease Susceptibility Antibodies	>6 publications with G-CSF and Disease Susceptibility
Nervous System Diseases Antibodies	>4 publications with G-CSF and Nervous System Diseases
Neutropenia Antibodies	>3 publications with G-CSF and Neutropenia
Leukopenia Antibodies	>2 publications with G-CSF and Leukopenia
Anemia Antibodies	>2 publications with G-CSF and Anemia
Leukemia, Myeloid, Acute Antibodies	>2 publications with G-CSF and Leukemia, Myeloid, Acute
Breast Neoplasms Antibodies	>1 publications with G-CSF and Breast Neoplasms
Peripheral Nervous System Diseases Antibodies	>1 publications with G-CSF and Peripheral Nervous System Diseases
Pulmonary Fibrosis Antibodies	>1 publications with G-CSF and Pulmonary Fibrosis
Brain Injuries Antibodies	>1 publications with G-CSF and Brain Injuries

Organs/Tissues associated with G-CSF recombinant protein

Organ/Tissue Name	Pubmed Publications
Skin Antibodies	>5 publications with G-CSF and Skin
Muscle Antibodies	>3 publications with G-CSF and Muscle
Lung Antibodies	>3 publications with G-CSF and Lung
Liver Antibodies	>1 publications with G-CSF and Liver
Brain Antibodies	>1 publications with G-CSF and Brain
Uterus Antibodies	>1 publications with G-CSF and Uterus
Uncharacterized Tissue Antibodies	>1 publications with G-CSF and Uncharacterized Tissue