Epididymis Protein 4, HE4 Human Recombinant Protein

Description: Recombinant full length human HE4 protein with molecular weight 14 kDa.

Background: WAP four-disulfide core domain protein 2, also known as Human Epididymis Protein 4 (HE4) is a protein that in humans is encoded by the WFDC2 gene. This gene is amplified in ovarian carcinomas, whereas its expression in normal tissues, including ovary, is low. Although the function of the HE4 protein is unknown, it is a member of a family of stable 4-disulfide core proteins that are secreted at high levels. HE4 is a secreted glycoprotein that is overexpressed by serous and endometrioid EOCs (epithelial ovarian carcinomas). Its expression in cortical inclusion cysts suggests that formation of Mullerian epithelium is a prerequisite step in the development of some types of EOCs.

1. Hellström, Ingegerd; John Raycraft, Martha Hayden-Ledbetter, Jeffrey A. Ledbetter, Michèl Schummer, Martin McIntosh, Charles Drescher, Nicole Urban, and Karl Erik Hellström (2003-07-01). "The HE4 (WFDC2) Protein Is a Biomarker for Ovarian Carcinoma". Cancer Research 63 (13): 3695-3700. 2. Drapkin R, von Horsten HH, Lin Y et al. (2005). "Human epididymis protein 4 (HE4) is a secreted glycoprotein that is overexpressed by serous and endometrioid ovarian carcinomas". Cancer Res. 65 (6): 2162-9.

Small volumes of Epididymis protein 4, HE4 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS355616 is a recombinant protein targeting Epididymis protein 4, HE4. Also known as Human Epididymis protein 4, HE4 Protein (Active). Host: E. coli.