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IL-13 Recombinant Protein

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS355617

Recombinant human IL-13 protein with molecular weight 12 kDa.Interleukin 13 (IL-13) is a protein that in humans is encoded by the IL13 gene which maps to 5q23-q31. It is cytokine secreted by many cell types, but especially T helper type 2 (Th2) cells, that is… More details

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Product Documentation
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Product Overview

Online Datasheet in PDF
Product Name
IL-13, Recombinant Protein
Full Product Name
IL-13 Protein (Active)
Product Gene Name
IL-13 recombinant protein
Product Synonym Names
Interleukin-13; IL-13; IL13; NC30; Interleukin-13; IL-13 Protein (Active)
Host
E Coli
Form/Format
Lyophilized
Preparation and Storage
Ship at 4 degree C. Upon receipt, store at -20 degree C or -80 degree C for 2 years. After reconstituting, it can store at 4 degree C for a week, it is recommended to add 0.1% HSA or BSA for long term. Avoid repeated freeze and thaw cycles
Molecular Weight
15,816 Da
Chromosome Location
Chromosome: 5; NC_000005.9 (131993865..131996801). Location: 5q31
OMIM
147683
3D Structure
ModBase 3D Structure for P35225
Dimers
< 1% by SDS-PAGE
Endotoxin Level
< 0.1 ng/ug (1 EU/ug) by LAL test
Reconstitution
Reconstitute with sterile 18MΩ-cm H2O.
Storage Buffer
Each vial contains 10 mM Phosphate buffer and 200 mM NaCl (pH7.0) without preservatives.
Applications Tested/Suitable for IL-13 recombinant protein
SDS-PAGE

Product References and Citations for IL-13 recombinant protein

1. Minty A, Chalon P, Derocq JM, Dumont X, Guillemot JC, Kaghad M, Labit C, Leplatois P, Liauzun P, Miloux B (March 1993). "Interleukin-13 is a new human lymphokine regulating inflammatory and immune responses". Nature 362 (6417): 248-50. 2. Paul, W. E. Personal Communication. Bethesda, Md. 3/6/1993. 3. Wynn TA (2003). "IL-13 effector functions". Annu. Rev. Immunol. 21: 425-56.

Other Notes

Small volumes of IL-13 recombinant protein vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for IL-13 purchase

MBS355617 is a recombinant protein targeting IL-13. Also known as IL-13 Protein (Active). Host: E Coli.

Additional Details

NCBI/Uniprot data below describe general gene information for IL-13. It may not necessarily be applicable to this product.

NCBI GI #
26787978
NCBI GeneID
3596
NCBI Accession #
NP_002179.2
UniProt Primary Accession #
P35225
UniProt Secondary Accession #
O43644; Q4VB52; Q9UDC7
UniProt Related Accession #
P35225
GenBank Nucleotide #
NM_002188.2
NCBI Official Full Name
interleukin-13
NCBI Official Synonym Full Names
interleukin 13
NCBI Official Symbol
IL13
NCBI Official Synonym Symbols
P600; IL-13
UniProt Protein Name
Interleukin-13
UniProt Gene Name
IL13
UniProt Synonym Gene Names
NC30; IL-13
UniProt Entry Name
IL13_HUMAN
NCBI Protein Information
interleukin-13

NCBI Summary for IL-13

This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]
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UniProt Comments for IL-13

Function: Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses.

Subunit structure: Interacts with IL13RA2.

Subcellular location: Secreted.

Involvement in disease: Allergic rhinitis (ALRH) [MIM:607154]: A common disease with complex inheritance characterized by mucosal inflammation caused by allergen exposure.Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.

Sequence similarities: Belongs to the IL-4/IL-13 family.

Caution: It is uncertain whether Met-1 or Met-15 is the initiator.

Sequence caution: The sequence AAA36107.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAA83738.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAB01681.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAC03535.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence AAK53823.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.The sequence CAA48824.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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Research Articles on IL-13

1. IL-13 SNP rs20541 exhibited increased AR risk in Asians.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with IL-13 recombinant protein

 Reference Product  PubMed Publications
 STAT6 recombinant protein  >384 publications with IL-13 and STAT6
 IL13RA1 recombinant protein  >287 publications with IL-13 and IL13RA1
 IL5 recombinant protein  >89 publications with IL-13 and IL5
 IL18 recombinant protein  >83 publications with IL-13 and IL18
 GATA3 recombinant protein  >83 publications with IL-13 and GATA3
 IL4R recombinant protein  >56 publications with IL-13 and IL4R
 TSLP recombinant protein  >28 publications with IL-13 and TSLP
 IL13RA2 recombinant protein  >12 publications with IL-13 and IL13RA2
 VCAM1 recombinant protein  >5 publications with IL-13 and VCAM1

Pathways associated with IL-13 recombinant protein

 Products by Pathway  Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Asthma Pathway antibodies  Asthma Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokine-cytokine Receptor Interaction Pathway antibodies  Cytokine-cytokine Receptor Interaction Pathway Diagram
 Cytokines And Inflammatory Response Pathway antibodies  Cytokines And Inflammatory Response Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Fc Epsilon RI Signaling Pathway antibodies  Fc Epsilon RI Signaling Pathway Diagram
 Glucocorticoid Receptor Regulatory Network Pathway antibodies  Glucocorticoid Receptor Regulatory Network Pathway Diagram
 IL12 Signaling Mediated By STAT4 Pathway antibodies  IL12 Signaling Mediated By STAT4 Pathway Diagram
 Inflammatory Bowel Disease (IBD) Pathway antibodies  Inflammatory Bowel Disease (IBD) Pathway Diagram

Diseases associated with IL-13 recombinant protein

 Disease Name  Pubmed Publications
 Hypersensitivity Antibodies  >1244 publications with IL-13 and Hypersensitivity
 Inflammation Antibodies  >1175 publications with IL-13 and Inflammation
 Asthma Antibodies  >1164 publications with IL-13 and Asthma
 Hypersensitivity, Immediate Antibodies  >1079 publications with IL-13 and Hypersensitivity, Immediate
 Lung Diseases Antibodies  >1057 publications with IL-13 and Lung Diseases
 Respiratory Hypersensitivity Antibodies  >898 publications with IL-13 and Respiratory Hypersensitivity
 Necrosis Antibodies  >570 publications with IL-13 and Necrosis
 Fibrosis Antibodies  >295 publications with IL-13 and Fibrosis
 Bronchial Hyperreactivity Antibodies  >213 publications with IL-13 and Bronchial Hyperreactivity
 Nervous System Diseases Antibodies  >177 publications with IL-13 and Nervous System Diseases

Organs/Tissues associated with IL-13 recombinant protein

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >160 publications with IL-13 and Brain
 Bone Marrow Antibodies  >128 publications with IL-13 and Bone Marrow
 Mixed Antibodies  >66 publications with IL-13 and Mixed
 Testis Antibodies  >6 publications with IL-13 and Testis
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