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GNE-477

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600157

A potent, dual PI3K/mTOR inhibitor with IC50 of 4 nM for PI3Kalpha, Ki of 21 nM for mTOR. More details

$240 / 2 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
GNE-477, Biochemical
Full Product Name
GNE-477
Product Synonym Names
GNE477; GNE 477
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
504.6288
Suitability
DMSO: <9.2mg/mL
Target
PI3K
Receptor
mTOR; PI3Kalpha
Chemical Name
2-Pyrimidinamine, 5-[7-methyl-6-[[4-(methylsulfonyl)-1-piperazinyl]methyl]-4-(4-morpholinyl)thieno[3, 2-d]pyrimidin-2-yl]
SMILES
NC1=NC=C(C2=NC(N3CCOCC3)=C4C(C(C)=C(CN5CCN(S(=O)(C)=O)CC5)S4)=N2)C=N1
Molecular Formula
C21H28N8O3S2
CAS Number
1032754-81-6

Product Categories/Family for GNE-477 biochemical

PI3K/Akt/mTOR signaling; Cancer

Structure of GNE-477 biochemical

GNE-477 Biochemical – Cat# MBS3600157

Product References and Citations for GNE-477 biochemical

1. Heffron TP, et al. Bioorg Med Chem Lett. 2010 Apr 15; 20 (8):2408-11.

Other Notes

Small volumes of GNE-477 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for GNE-477 purchase

MBS3600157 is a biochemical targeting GNE-477.
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