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COTI-2

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600200

COTI-2 (COTI2) is an orally available thiosemicarbazone that may act on mutant forms of p53 and PI3K/AKT/mTOR pathway. More details

$220 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
PDF
Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
COTI-2, Biochemical
Full Product Name
COTI-2
Product Synonym Names
COTI2
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
366.5
Suitability
DMSO: 10mM (<1mg/mL refers to the product slightly soluble or insoluble)
Target
MDM2-p53
Receptor
p53mutants
Chemical Name
4-(2-pyridinyl)-2-(6, 7-dihydro-8(5H)-quinolinylidene)hydrazide-1-piperazinecarbothioic acid
SMILES
S=C(N1CCN(C2=NC=CC=C2)CC1)N/N=C3CCCC4=C3N=CC=C4
Molecular Formula
C19H22N6S
CAS Number
1039455-84-9

Product Categories/Family for COTI-2 biochemical

Ovarian Cancer; Apoptosis; Cancer

Structure of COTI-2 biochemical

COTI-2 Biochemical – Cat# MBS3600200

Product References and Citations for COTI-2 biochemical

1. Salim KY, et al. Oncotarget. 2016 Jul 5; 7 (27):41363-41379.
2. Duffy MJ, et al. Eur J Cancer. 2017 Jul 27; 83:258-265.
3. Heffeter P, et al. Antioxid Redox Signal. 2018 Jan 15. doi: 10.1089/ars.2017.7487.

Other Notes

Small volumes of COTI-2 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for COTI-2 purchase

MBS3600200 is a biochemical targeting COTI-2.
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