DEBIO 1143 (AT-406)

Name: DEBIO 1143 (AT-406); MyBioSource
Brand: MyBioSource
SKU: MBS3600293
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600293

DEBIO 1143 (AT-406, DEBIO-1143, SM406, ARRY-334543, D1143) is potent, orally active Smac mimetic that antagonizes cIAP1, cIAP2 and XIAP with Ki of 66.4, 1.9 and 5.1 nM, respectively. More details

$235 / 2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

DEBIO 1143, Biochemical

Full Product Name

DEBIO 1143

Product Synonym Names

AT-406; DEBIO1143; SM406; ARRY-334543; D1143

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

561.727

Suitability

DMSO: 93mg/mL (165.6mM)
Ethanol: 93mg/mL (165.6mM)
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)

Target

Other Targets

Receptor

cIAP1-BIR3; cIAP2-BIR3; XIAP-BIR3

Chemical Name

(5S, 8S, 10aR)-N-benzhydryl-5-((S)-2-(methylamino)propanamido)-3-(3-methylbutanoyl)-6-oxodecahydropyrrolo[1, 2-a][1, 5]diazocine-8-carboxamide

SMILES

CC(C)CC(=O)N1CCC2CCC(N2C(=O)C(C1)NC(=O)C(C)NC)C(=O)NC(C3=CC=CC=C3)C4=CC=CC=C4

Molecular Formula

C32H43N5O4

CAS Number

1071992-99-8

Product Categories/Family for DEBIO 1143 biochemical

Ovarian Cancer; Cancer

Product References and Citations for DEBIO 1143 biochemical

1. Cai Q, et al. J Med Chem. 2011 Apr 28; 54 (8):2714-26.
2. Langdon CG, et al. Oncotarget. 2015 Nov 10; 6 (35):37410-25.
3. Tao Z, et al. Clin Cancer Res. 2018 Oct 23. doi: 10.1158/1078-0432.
4. Thibault B, et al. Sci Rep. 2018 Dec 14; 8 (1):17862.

Other Notes

Small volumes of DEBIO 1143 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for DEBIO 1143 purchase

MBS3600293 is a biochemical targeting DEBIO 1143.