Glasdegib (PF-04449913)

Name: Glasdegib (PF-04449913); MyBioSource
Brand: MyBioSource
SKU: MBS3600371
Price: 260 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600371

Glasdegib (PF-04449913) is a potent, orally bioavailable smoothened (SMO) inhibitor with IC50 of 5 nM in the Gli-luciferase reporter assays. More details

$260 / 5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Glasdegib, Biochemical

Full Product Name

Glasdegib

Product Synonym Names

PF-04449913; PF04449913

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

374.448

Suitability

DMSO: >=83.33mg/mL (222.55mM)

Target

Smoothened (Smo)

Receptor

Smoothened

Chemical Name

1-((2R, 4R)-2-(1H-benzo[d]imidazol-2-yl)-1-methylpiperidin-4-yl)-3-(4-cyanophenyl)urea

SMILES

O=C(NC1=CC=C(C#N)C=C1)N[C@H]2C[C@H](C3=NC4=CC=CC=C4N3)N(C)CC2

Molecular Formula

C21H22N6O

CAS Number

1095173-27-5

Product Categories/Family for Glasdegib biochemical

Blood cancer; Wnt/Notch/Hedgehog; Cancer

Product References and Citations for Glasdegib biochemical

1. Munchhof MJ, et al. ACS Med Chem Lett. 2011 Dec 21; 3 (2):106-11.
2. Wagner AJ, et al. Clin Cancer Res. 2015 Mar 1; 21 (5):1044-51.
3. Sadarangani A, et al. J Transl Med. 2015 Mar 21; 13:98.
4. Martinelli G, et al. Lancet Haematol. 2015 Aug; 2 (8):e339-46.

Other Notes

Small volumes of Glasdegib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Glasdegib purchase

MBS3600371 is a biochemical targeting Glasdegib.