Entrectinib (NMS-E628)

Name: Entrectinib (NMS-E628); MyBioSource
Brand: MyBioSource
SKU: MBS3600406
Price: 220 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600406

Entrectinib (NMS-E628, RXDX-101, NMS-01191372) is a potent, ATP-competitive, orally available pan-TRK, ROS1 and ALK inhibitor with IC50 of 1/3/5/12/7 nM for TRKA/TRKB/TRKC/ALK/ROS1, respectively. More details

$220 / 2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Entrectinib, Biochemical

Full Product Name

Entrectinib

Product Synonym Names

NMS-E628; RXDX-101;nMS-01191372

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

560.6375

Suitability

DMSO: >=31mg/mL

Target

Trk Receptor

Receptor

ALK; ROS1; TrkA; TrkB; TrkC

Chemical Name

Benzamide, N-[5-[(3, 5-difluorophenyl)methyl]-1H-indazol-3-yl]-4-(4-methyl-1-piperazinyl)-2-[(tetrahydro-2H-pyran-4-yl)amino]

SMILES

O=C(NC1=NNC2=C1C=C(CC3=CC(F)=CC(F)=C3)C=C2)C4=CC=C(N5CCN(C)CC5)C=C4NC6CCOCC6

Molecular Formula

C31H34F2N6O2

CAS Number

1108743-60-7

Product Categories/Family for Entrectinib biochemical

Lung Cancer; Tyrosine Kinase; Cancer

Product References and Citations for Entrectinib biochemical

1. Menichincheri M, et al. J Med Chem. 2016 Apr 14; 59 (7):3392-408.
2. Ardini E, et al. Mol Cancer Ther. 2016 Apr; 15 (4):628-39.
3. Rolfo C, et al. Expert Opin Investig Drugs. 2015; 24 (11):1493-500.
4. Russo M, et al. Cancer Discov. 2016 Jan; 6 (1):36-44.

Other Notes

Small volumes of Entrectinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Entrectinib purchase

MBS3600406 is a biochemical targeting Entrectinib.