Dacomitinib (PF-00299804)

Name: Dacomitinib (PF-00299804); MyBioSource
Brand: MyBioSource
SKU: MBS3600413
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600413

Dacomitinib (PF-00299804, PF-299804) is a potent, irreversible, orally active pan-ErbB receptor tyrosine kinase inhibitor with IC50 of 6, 45.7 and 73.7 for EGFR, ERBB2 and ERBB4, respectively. More details

$235 / 2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Dacomitinib, Biochemical

Full Product Name

Dacomitinib

Product Synonym Names

PF-00299804; PF-299804; PF 299804; PF 00299804

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

469.9

Suitability

DMSO: >=50mg/mL (Need ultrasonic)

Target

EGFR

Receptor

EGFR; HER2/ErbB2

Chemical Name

2-Butenamide, N-[4-[(3-chloro-4-fluorophenyl)amino]-7-methoxy-6-quinazolinyl]-4-(1-piperidinyl)-, (2E)

SMILES

COC1=C(C=C2C(=C1)N=CN=C2NC3=CC(=C(C=C3)F)Cl)NC(=O)/C=C/CN4CCCCC4

Molecular Formula

C24H25ClFN5O2

CAS Number

1110813-31-4

Product Categories/Family for Dacomitinib biochemical

Lung Cancer; Angiogenesis; Cancer

Product References and Citations for Dacomitinib biochemical

1. Engelman JA, et al. Cancer Res. 2007 Dec 15; 67 (24):11924-32.
2. Gonzales AJ, et al. Mol Cancer Ther. 2008 Jul; 7 (7):1880-9.
3. Nguyen KS, et al. Clin Lung Cancer. 2009 Jul; 10 (4):281-9.
4. Kalous O, et al. Mol Cancer Ther. 2012 Sep; 11 (9):1978-87.

Other Notes

Small volumes of Dacomitinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Dacomitinib purchase

MBS3600413 is a biochemical targeting Dacomitinib.