Ivacaftor Hydrate (VX-770 hydrate)

Name: Ivacaftor Hydrate (VX-770 hydrate); MyBioSource
Brand: MyBioSource
SKU: MBS3600469
Price: 875 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600469

Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. More details

$875 / 5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Ivacaftor hydrate, Biochemical

Full Product Name

Ivacaftor hydrate

Product Synonym Names

VX-770 hydrate; VX 770 hydrate; VX770 hydrate

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

410.506

Suitability

10mM in DMSO

Target

CFTR

Receptor

CFTR

Chemical Name

3-Quinolinecarboxamide, N-[2, 4-bis(1, 1-dimethylethyl)-5-hydroxyphenyl]-1, 4-dihydro-4-oxo-, hydrate(1:1)

SMILES

CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C.O

Molecular Formula

C24H30N2O4

CAS Number

1134822-07-3

Product Categories/Family for Ivacaftor hydrate biochemical

Fibrosis; Apoptosis; Other Indications

Product References and Citations for Ivacaftor hydrate biochemical

1. Van Goor F, et al. Proc Natl Acad Sci U S A. 2009 Nov 3; 106 (44):18825-30.
2. Accurso FJ, et al. N Engl J Med. 2010 Nov 18; 363 (21):1991-2003.
3. Yu W, et al. J Biol Chem. 2011 Jul 15; 286 (28):24714-25.
4. Hadida S, et al. J Med Chem. 2014 Dec 11; 57 (23):9776-95.

Other Notes

Small volumes of Ivacaftor hydrate biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ivacaftor hydrate purchase

MBS3600469 is a biochemical targeting Ivacaftor hydrate.