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Ivacaftor benzenesulfonate

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600470

Ivacaftor (VX-770, VX770) is a potent, orally bioavailable CFTR potentiator, increases G551D- and F508del CFTR-mediated Cl- secretion with EC50 of 100 nM. More details

$875 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Ivacaftor benzenesulfonate, Biochemical
Full Product Name
Ivacaftor benzenesulfonate
Product Synonym Names
VX-770 benzenesulfonate; VX 770 benzenesulfonate
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
550.6658
Suitability
10mM in DMSO
Target
CFTR
Receptor
CFTR
Chemical Name
3-Quinolinecarboxamide, N-[2, 4-bis(1, 1-dimethylethyl)-5-hydroxyphenyl]-1, 4-dihydro-4-oxo-, benzenesulfonate(1:1)
SMILES
CC(C)(C)C1=CC(=C(C=C1NC(=O)C2=CNC3=CC=CC=C3C2=O)O)C(C)(C)C.C1=CC=C(C=C1)S(=O)(=O)O
Molecular Formula
C30H34N2O6S
CAS Number
1134822-09-5

Product Categories/Family for Ivacaftor benzenesulfonate biochemical

Fibrosis; Apoptosis; Other Indications

Structure of Ivacaftor benzenesulfonate biochemical

Ivacaftor Benzenesulfonate Biochemical – Cat# MBS3600470

Product References and Citations for Ivacaftor benzenesulfonate biochemical

1. Van Goor F, et al. Proc Natl Acad Sci U S A. 2009 Nov 3; 106 (44):18825-30.
2. Accurso FJ, et al. N Engl J Med. 2010 Nov 18; 363 (21):1991-2003.
3. Yu W, et al. J Biol Chem. 2011 Jul 15; 286 (28):24714-25.
4. Hadida S, et al. J Med Chem. 2014 Dec 11; 57 (23):9776-95.

Other Notes

Small volumes of Ivacaftor benzenesulfonate biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Ivacaftor benzenesulfonate purchase

MBS3600470 is a biochemical targeting Ivacaftor benzenesulfonate.
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