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E7449

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600499

E7449 (2X-121) is a potent, orally bioavailable, brain penetrable dual inhibitor of PARP1/2 and TNKS1/2 with IC50 of 2.0/1.0 nM (PARP1/2), 50-100 nM (TNKS1/2). More details

$260 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
E7449, Biochemical
Full Product Name
E7449
Product Synonym Names
E-7449; 2X-121
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
317.3446
Suitability
DMSO: <6.96mg/mL
Target
PARP
Receptor
PARP
Chemical Name
3H-Pyridazino[3, 4, 5-de]quinazolin-3-one, 8-[(1, 3-dihydro-2H-isoindol-2-yl)methyl]-1, 2-dihydro
SMILES
O=C1NN=C(N2)C3=C(C=CC=C31)N=C2CN(C4)CC5=C4C=CC=C5
Molecular Formula
C18H15N5O
CAS Number
1140964-99-3

Product Categories/Family for E7449 biochemical

Breast Cancer; Cell Cycle/DNA Damage; Cancer

Structure of E7449 biochemical

E7449 Biochemical – Cat# MBS3600499

Product References and Citations for E7449 biochemical

1. McGonigle S, et al. Oncotarget. 2015 Dec 1; 6 (38):41307-23.
2. Sharon McGonigle, et al. Abstract 4688: E7449: A novel PARP inhibitor enhances the efficacy of radiotherapy and chemotherapy and has potent single agent anticancer activity in BRCA-deficient tumors. Cancer Research: April 15, 2012; Volume 72, Issue 8, Su

Other Notes

Small volumes of E7449 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for E7449 purchase

MBS3600499 is a biochemical targeting E7449.
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