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MRT67307

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600651

MRT67307 is a potent, dual inhibitor of IKKepsilon and TBK-1 with IC50 of 160 and 19 nM at 0.1 mM ATP in vitro, also potently inhibit ULK1 and ULK2 in vitro (IC50=45 and 38 nM) and block autophagy in cells. More details

$255 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MRT67307, Biochemical
Full Product Name
MRT67307
Product Synonym Names
MRT 67307; MRT-67307
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
464.603
Suitability
10mM in DMSO
Target
ULK
Receptor
IKK; TBK1
Chemical Name
Cyclobutanecarboxamide, N-[3-[[5-cyclopropyl-2-[[3-(4-morpholinylmethyl)phenyl]amino]-4-pyrimidinyl]amino]propyl]
SMILES
C1CC(C1)C(=O)NCCCNC2=NC(=NC=C2C3CC3)NC4=CC=CC(=C4)CN5CCOCC5
Molecular Formula
C26H36N6O2
CAS Number
1190378-57-4

Product Categories/Family for MRT67307 biochemical

Autophagy; Inflammation/Immunology

Structure of MRT67307 biochemical

MRT67307 Biochemical – Cat# MBS3600651

Product References and Citations for MRT67307 biochemical

1. Clark K, et al. Biochem J. 2011 Feb 15; 434 (1):93-104.
2. Clark K, et al. Proc Natl Acad Sci U S A. 2012 Oct 16; 109 (42):16986-91.
3. Petherick KJ, et al. J Biol Chem. 2015 May 1; 290 (18):11376-83.

Other Notes

Small volumes of MRT67307 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRT67307 purchase

MBS3600651 is a biochemical targeting MRT67307.
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