LOXO-101 (ARRY470)

Name: LOXO-101 (ARRY470); MyBioSource
Brand: MyBioSource
SKU: MBS3600854
Price: 255 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600854

LOXO-101 (ARRY-470, Larotrectinib) is potent, selective pan-TRK inhibitor with cellular IC50 of 2-20 nM against TRKA, TRKB, and TRKC kinases. More details

$255 / 5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

LOXO-101, Biochemical

Full Product Name

LOXO-101

Product Synonym Names

ARRY470; ARRY-470; ARRY 470; LOXO 101; LOXO101; Larotrectinib

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

428.4352

Suitability

DMSO: >=4.6mg/mL

Target

Trk Receptor

Receptor

Trk Receptor

Chemical Name

1-Pyrrolidinecarboxamide, N-[5-[(2R)-2-(2, 5-difluorophenyl)-1-pyrrolidinyl]pyrazolo[1, 5-a]pyrimidin-3-yl]-3-hydroxy-, (3S)

SMILES

C1CC(N(C1)C2=NC3=C(C=NN3C=C2)NC(=O)N4CCC(C4)O)C5=C(C=CC(=C5)F)F

Molecular Formula

C21H22F2N6O2

CAS Number

1223403-58-4

Product Categories/Family for LOXO-101 biochemical

Blood cancer; Tyrosine Kinase; Cancer

Product References and Citations for LOXO-101 biochemical

1. Doebele RC, et al. Cancer Discov. 2015 Oct; 5 (10):1049-57.
2. Ghilardi JR, et al. Mol Pain. 2010 Dec 7; 6:87.
3. Vaishnavi A, et al. Nat Med. 2013 Nov; 19 (11):1469-1472.
4. Drilon A, et al. N Engl J Med. 2018 Feb 22; 378 (8):731-739.

Other Notes

Small volumes of LOXO-101 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LOXO-101 purchase

MBS3600854 is a biochemical targeting LOXO-101.