Roniciclib (BAY 10-00394)

Name: Roniciclib (BAY 10-00394); MyBioSource
Brand: MyBioSource
SKU: MBS3600856
Price: 290 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600856

A novel potent, orally active, pan-CDK inhibitor with IC50 of 7/9/11 nM for CDK1/2/4 respectively, inhibits transcriptional CDK9/7 with IC50 of 5-25 nM. More details

$290 / 5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Roniciclib, Biochemical

Full Product Name

Roniciclib

Product Synonym Names

BAY 10-00394; BAY1000394

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

430.44

Target

CDK

Receptor

CDK

Chemical Name

(R)-S-Cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulfoximide

SMILES

C[C@@H](O)[C@H](OC1=NC(NC2=CC=C(S(=N)(C3CC3)=O)C=C2)=NC=C1C(F)(F)F)C

Molecular Formula

C18H21F3N4O3S

CAS Number

1223498-69-8

Product Categories/Family for Roniciclib biochemical

Lung Cancer; Angiogenesis; Cancer

Product References and Citations for Roniciclib biochemical

1. Siemeister G, et al. Mol Cancer Ther. 2012 Oct; 11 (10):2265-73.
2. Lucking U, et al. ChemMedChem. 2013 Jul; 8 (7):1067-85.
3. Ayaz P, et al. ACS Chem Biol. 2016 Jun 17; 11 (6):1710-9.
4. Bahleda R, et al. Br J Cancer. 2017 Jun 6; 116 (12):1505-1512.

Other Notes

Small volumes of Roniciclib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Roniciclib purchase

MBS3600856 is a biochemical targeting Roniciclib.