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LRRK2-IN-1

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3600936

A potent LRRK2 inhibitor with IC50s of 13 nM/6 nM for wild-type/G2019S mutant LRRK2 repectively (0.1 mM ATP in the assay). More details

$240 / 5 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LRRK2-IN-1, Biochemical
Full Product Name
LRRK2-IN-1
Product Synonym Names
LRRK 2-IN-1
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
570.6852
Suitability
10mM in DMSO
Target
LRRK2
Receptor
DCLK1; DCLK2; LRRK2 (A2016T); LRRK2 (G2019S); LRRK2 (WT)
Chemical Name
6H-Pyrimido[4, 5-b][1, 4]benzodiazepin-6-one, 5, 11-dihydro-2-[[2-methoxy-4-[[4-(4-methyl-1-piperazinyl)-1-piperidinyl]carbonyl]phenyl]amino]-5, 11-dimethyl
SMILES
O=C1N(C)C2=CN=C(NC3=CC=C(C(N4CCC(N5CCN(C)CC5)CC4)=O)C=C3OC)N=C2N(C)C6=CC=CC=C16
Molecular Formula
C31H38N8O3
CAS Number
1234480-84-2

Product Categories/Family for LRRK2-IN-1 biochemical

Autophagy; Neurological Disease

Structure of LRRK2-IN-1 biochemical

LRRK2-IN-1 Biochemical – Cat# MBS3600936

Product References and Citations for LRRK2-IN-1 biochemical

1. Deng X, et al. Nat Chem Biol. 2011 Apr; 7 (4):203-5.
2. Weygant N, et al. Mol Cancer. 2014 May 6; 13:103.
3. Luerman GC, et al. J Neurochem. 2014 Feb; 128 (4):561-76.

Other Notes

Small volumes of LRRK2-IN-1 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LRRK2-IN-1 purchase

MBS3600936 is a biochemical targeting LRRK2-IN-1.
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