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TAK-438

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3601071

A novel potent, potassium-competitive acid blocker (P-CAB) that inhibits H(+),K(+)-ATPase activity in porcine gastric microsomes with IC50 of 19 nM at pH 6.5. More details

$220 / 100 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
PDF
Technical Datasheet View PDF
PDF
Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
TAK-438, Biochemical
Full Product Name
TAK-438
Product Synonym Names
TAK 438; TAK438; Vonoprazan
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
461.464
Suitability
DMSO: 58mg/mL (125.7mM)
Ethanol: <1mg/mL
Water: <1mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)
Target
Proton Pump
Receptor
H+/K+-ATPase
Chemical Name
1-[5-(2-fluorophenyl)-1-(pyridin-3-ylsulfonyl)-1H-pyrrol-3-yl]-N-methylmethanamine monofumarate
SMILES
CNCC1=CN(C(=C1)C2=CC=CC=C2F)S(=O)(=O)C3=CN=CC=C3.C(=C/C(=O)O)C(=O)O
Molecular Formula
C21H20FN3O6S
CAS Number
1260141-27-2

Product Categories/Family for TAK-438 biochemical

Ulcer; Membrane Transporter/Ion Channel; Other Indications

Structure of TAK-438 biochemical

TAK-438 Biochemical – Cat# MBS3601071

Product References and Citations for TAK-438 biochemical

1. Arikawa Y, et al. J Med Chem. 2012 May 10; 55 (9):4446-56.
2. Hori Y, et al. J Pharmacol Exp Ther. 2010 Oct; 335 (1):231-8.
3. Matsukawa J, et al. Biochem Pharmacol. 2011 May 1; 81 (9):1145-51.
4. Shin JM, et al. J Pharmacol Exp Ther. 2011 Nov; 339 (2):412-20.

Other Notes

Small volumes of TAK-438 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for TAK-438 purchase

MBS3601071 is a biochemical targeting TAK-438.
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