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S44819

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3601664

S44819 (S-44819, Egis-1352 Afizagabar) is a novel potent, competitive, selective antagonist of the alpha5-GABAAR with Kd of 221 nM, IC50 of 585 nM (alpha5beta2gamma2). More details

$1095 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
S44819, Biochemical
Full Product Name
S44819
Product Synonym Names
S-44819; Egis-13529; Afizagabar
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
365.382
Target
iGluR
Receptor
iGluR
Chemical Name
5-(4-Fluoro-1-benzothiophen-2-yl)-8-methyl-1, 9-dihydro2H-[1, 3]oxazolo[4, 5-H][2, 3]benzodiazepin-2-one
SMILES
O=C(N1)OC2=C1C=C3CC(C)=NN=C(C4=CC5=C(F)C=CC=C5S4)C3=C2
Molecular Formula
C19H12FN3O2S
CAS Number
1398496-82-6

Product Categories/Family for S44819 biochemical

Stroke; Membrane Transporter/Ion Channel; Neurological Disease

Structure of S44819 biochemical

S44819 Biochemical – Cat# MBS3601664

Product References and Citations for S44819 biochemical

1. Darmani G, et al. J Neurosci. 2016 Dec 7; 36 (49):12312-12320.
2. Gacsalyi I, et al. Neuropharmacology. 2017 Oct; 125:30-38.
3. Etherington LA, et al. Neuropharmacology. 2017 Oct; 125:353-364.
4. Gacsalyi I, et al. Eur J Pharmacol. 2018 Jul 21; 834:118-125.

Other Notes

Small volumes of S44819 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for S44819 purchase

MBS3601664 is a biochemical targeting S44819.
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