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PF-06459988

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3601808

PF-06459988 (PF06459988, PF 6459988) is a potent, selective, irreversible EGFR mutants with IC50 of 13, 7, 21 and 90 nM for EGFR L858R-T790M, Del-T790M, L858R, and EGFR Del, respectively. More details

$475 / 50 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PF-06459988, Biochemical
Full Product Name
PF-06459988
Product Synonym Names
PF 06459988; PF06459988; PF 6459988
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
431.88
Suitability
DMSO: 50mg/mL (115.77mM)
Target
EGFR
Receptor
EGFR
Chemical Name
1-[(3R, 4R)-3-[[[5-Chloro-2-[(1-methyl-1H-pyrazol-4-yl)amino]-7H-pyrrolo[2, 3-d]pyrimidin-4-yl]oxy]methyl]-4-methoxy-1-pyrrolidinyl]-2-propen-1-one
SMILES
C=CC(N1C[C@H](COC2=C3C(NC=C3Cl)=NC(NC4=CN(C)N=C4)=N2)[C@@H](OC)C1)=O
Molecular Formula
C19H22ClN7O3
CAS Number
1428774-45-1

Product Categories/Family for PF-06459988 biochemical

Lung Cancer; Angiogenesis; Cancer

Structure of PF-06459988 biochemical

Pf-06459988 Biochemical – Cat# MBS3601808

Product References and Citations for PF-06459988 biochemical

1. Cheng H, et al. J Med Chem. 2016 Mar 10; 59 (5):2005-24.
2. Planken S, et al. J Med Chem. 2017 Apr 13; 60 (7):3002-3019.

Other Notes

Small volumes of PF-06459988 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF-06459988 purchase

MBS3601808 is a biochemical targeting PF-06459988.
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