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AZD8186

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3602409

AZD8186 is a potent, isoform-specific PI3Kbeta inhibitor with IC50 of 4 nM, also inhibits PI3Kdelta (IC50=12 nM) with selectivity over PI3Kalpha (IC50=35 nM) and PI3Kgamma (IC50=675 nM). More details

$220 / 2 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
AZD8186, Biochemical
Full Product Name
AZD8186
Product Synonym Names
AZD-8186
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
457.4698
Suitability
DMSO: >=35mg/mL
Target
PI3K
Receptor
PI3Kalpha; PI3Kbeta; PI3Kgamma; PI3Kdelta
Chemical Name
4H-1-Benzopyran-6-carboxamide, 8-[(1R)-1-[(3, 5-difluorophenyl)amino]ethyl]-N, N-dimethyl-2-(4-morpholinyl)-4-oxo
SMILES
O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4)=O)=C1
Molecular Formula
C24H25F2N3O4
CAS Number
1627494-13-6

Product Categories/Family for AZD8186 biochemical

Breast Cancer; PI3K/Akt/mTOR signaling; Cancer

Structure of AZD8186 biochemical

AZD8186 Biochemical – Cat# MBS3602409

Product References and Citations for AZD8186 biochemical

1. Hancox U, et al. Mol Cancer Ther. 2015 Jan; 14 (1):48-58.
2. Barlaam B, et al. J Med Chem. 2015 Jan 22; 58 (2):943-62.
3. Schwartz S, et al. Cancer Cell. 2015 Jan 12; 27 (1):109-22.
4. Lynch JT, et al. Clin Cancer Res. 2017 Dec 15; 23 (24):7584-7595.

Other Notes

Small volumes of AZD8186 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for AZD8186 purchase

MBS3602409 is a biochemical targeting AZD8186.
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