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A-1210477

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3602546

A-1210477 is a potent, selective Mcl-1 inhibitor that bind to Mcl-1 (Ki=0.45 nM) to disrupt MCL-1-BIM complexes. More details

$220 / 2 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
A-1210477, Biochemical
Full Product Name
A-1210477
Product Synonym Names
A1210477
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
850.0366
Suitability
DMSO: <4.8mg/mL
Target
Bcl-2
Receptor
Mcl-1
Chemical Name
1H-Indole-2-carboxylic acid, 7-[5-[[4-[4-[(dimethylamino)sulfonyl]-1-piperazinyl]phenoxy]methyl]-1, 3-dimethyl-1H-pyrazol-4-yl]-1-[2-(4-morpholinyl)ethyl]-3-[3-(1-naphthalenyloxy)propyl]
SMILES
O=C(C(N1CCN2CCOCC2)=C(CCCOC3=C(C=CC=C4)C4=CC=C3)C5=C1C(C6=C(COC7=CC=C(N8CCN(S(=O)(N(C)C)=O)CC8)C=C7)N(C)N=C6C)=CC=C5)O
Molecular Formula
C46H55N7O7S
CAS Number
1668553-26-1

Product Categories/Family for A-1210477 biochemical

Angiogenesis; Cancer

Structure of A-1210477 biochemical

A-1210477 Biochemical – Cat# MBS3602546

Product References and Citations for A-1210477 biochemical

1. Leverson JD, et al. Cell Death Dis. 2015 Jan 15; 6:e1590.
2. Xiao Y, et al. Mol Cancer Ther. 2015 Aug; 14 (8):1837-47.
3. Phillips DC, et al. Blood Cancer J. 2015 Nov 13; 5:e368.
4. Karpel-Massler G, et al. Cancer Res. 2017 Jul 1; 77 (13):3513-3526.

Other Notes

Small volumes of A-1210477 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for A-1210477 purchase

MBS3602546 is a biochemical targeting A-1210477.
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