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PT2385

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3602551

PT2385 (PT-2385) is a potent, selective, and orally active antagonist of HIF2alpha, binds to HIF2alpha PAS-B domain (Kd=50 nM) and disrupts HIF2alpha/ARNT dimer formation. More details

$260 / 2 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PT2385, Biochemical
Full Product Name
PT2385
Product Synonym Names
PT-2385
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
383.3417
Suitability
10mM in DMSO
Target
HIF/HIF Prolyl-hydroxylase
Receptor
HIF/HIF Prolyl-hydroxylase
Chemical Name
Benzonitrile, 3-[[(1S)-2, 2-difluoro-2, 3-dihydro-1-hydroxy-7-(methylsulfonyl)-1H-inden-4-yl]oxy]-5-fluoro
SMILES
CS(C(C=C1)=C2C(CC(F)(F)[C@H]2O)=C1OC3=CC(C#N)=CC(F)=C3)(=O)=O
Molecular Formula
C17H12F3NO4S
CAS Number
1672665-49-4

Product Categories/Family for PT2385 biochemical

Kidney Cancer; Angiogenesis; Cancer

Structure of PT2385 biochemical

PT2385 Biochemical – Cat# MBS3602551

Product References and Citations for PT2385 biochemical

1. Wallace EM, et al. Cancer Res. 2016 Sep 15; 76 (18):5491-500.
2. Chen W, et al. Nature. 2016 Nov 3; 539 (7627):112-117.
3. Courtney KD, et al. J Clin Oncol. 2018 Mar 20; 36 (9):867-874.
4. Xie C, et al. Nat Med. 2017 Nov; 23 (11):1298-1308.

Other Notes

Small volumes of PT2385 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PT2385 purchase

MBS3602551 is a biochemical targeting PT2385.
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