Avapritinib (BLU-285)

Name: Avapritinib (BLU-285); MyBioSource
Brand: MyBioSource
SKU: MBS3602603
Price: 255 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3602603

Avapritinib (BLU-285) is a potent and highly selective inhibitor of mutant KIT and PDGFRalpha with IC50 of 0.6, 0.27 and 0.24 nM for KIT del557-558, KIT D816V and PDGFRA D842V, respectively. More details

$255 / 5 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Avapritinib, Biochemical

Full Product Name

Avapritinib

Product Synonym Names

BLU-285; BLU285

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

498.57

Suitability

DMSO: 65mg/mL
Water: Insoluble
Ethanol: 3mg/mL (<1mg/mL refers to the product slightly soluble or insoluble)

Target

c-Kit

Receptor

KITD816V; PDGFRalphaD842V

Chemical Name

(1S)-1-(4-fluorophenyl)-1-[2-[4-[6-(1-methylpyrazol-4-yl)pyrrolo[2, 1-f][1, 2, 4]triazin-4-yl]piperazin-1-yl]pyrimidin-5-yl]ethanamine

SMILES

CN1N=CC(C2=CN3C(C(N4CCN(C5=NC=C([C@@](C)(N)C6=CC=C(F)C=C6)C=N5)CC4)=NC=N3)=C2)=C1

Molecular Formula

C26H27FN10

CAS Number

1703793-34-3

Product Categories/Family for Avapritinib biochemical

Gastric Cancer; Angiogenesis; Cancer

Product References and Citations for Avapritinib biochemical

1. Cancer Discov. 2017 Dec 12. doi: 10.1158/2159-8290.
2. Evans EK, et al. Sci Transl Med. 2017 Nov 1; 9 (414). pii: eaao1690.
3. Cancer Discov. 2018 Jan; 8 (1):OF20. doi: 10.1158/2159-8290.

Other Notes

Small volumes of Avapritinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Avapritinib purchase

MBS3602603 is a biochemical targeting Avapritinib.