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PF-06751979

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3602796

PF-06751979 is a potent, selective, brain penetrant BACE1 inhibitor with binding IC50 of 7.3, 27-fold selectivity over BACE2. More details

$1345 / 50 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
PF-06751979, Biochemical
Full Product Name
PF-06751979
Product Synonym Names
PF06751979
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
455.499
Suitability
DMSO: 150mg/mL (329.31mM)
Ethanol: 50mg/mL (109.77mM)
Target
BACE
Receptor
BACE
Chemical Name
N-(2-((4aR, 6S, 8aR)-2-amino-6-methyl-4, 4a, 5, 6-tetrahydropyrano[3, 4-d][1, 3]thiazin-8a(8H)-yl)thiazol-4-yl)-5-(difluoromethoxy)picolinamide
SMILES
CC1CC2CSC(=NC2(CO1)C3=NC(=CS3)NC(=O)C4=NC=C(C=C4)OC(F)F)N
Molecular Formula
C18H19F2N5O3S2
CAS Number
1818339-66-0

Product Categories/Family for PF-06751979 biochemical

Alzheimer Disease; Metabolic Enzyme/Protease; Neurological Disease

Structure of PF-06751979 biochemical

Pf-06751979 Biochemical – Cat# MBS3602796

Product References and Citations for PF-06751979 biochemical

1. O'Neill BT, et al. J Med Chem. 2018 Apr 3. doi: 10.1021/acs.jmedchem.8b00246.

Other Notes

Small volumes of PF-06751979 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for PF-06751979 purchase

MBS3602796 is a biochemical targeting PF-06751979.
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