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ARV-825

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3602800

ARV-825 is a hetero-bifunctional PROTAC (Proteolysis Targeting Chimera) that recruits BRD4 to the E3 ubiquitin ligase cereblon, leading to fast, efficient, and prolonged degradation of BRD4 via the proteasome. More details

$300 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ARV-825, Biochemical
Full Product Name
ARV-825
Product Synonym Names
ARV 825; ARV825
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
923.4316
Suitability
10mM in DMSO
Target
Bromodomain
Receptor
Bromodomain
Chemical Name
2-((S)-4-(4-chlorophenyl)-2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl)-N-(4-(2-(2-(2-(2-((2-(2, 6-dioxopiperidin-3-yl)-1, 3-dioxoisoindolin-4-yl)amino)ethoxy)ethoxy)ethoxy)ethoxy)phenyl)acetamide
SMILES
O=C(NC1=CC=C(OCCOCCOCCOCCNC2=CC=CC(C(N3C(CC4)C(NC4=O)=O)=O)=C2C3=O)C=C1)C[C@H]5C6=NN=C(C)N6C7=C(C(C)=C(C)S7)C(C8=CC=C(Cl)C=C8)=N5
Molecular Formula
C46H47ClN8O9S
CAS Number
1818885-28-7

Product Categories/Family for ARV-825 biochemical

Chromatin/Epigenetic; Cancer

Structure of ARV-825 biochemical

ARV-825 Biochemical – Cat# MBS3602800

Product References and Citations for ARV-825 biochemical

1. Lu J, et al. Chem Biol. 2015 Jun 18; 22 (6):755-63.
2. Abruzzese MP, et al. J Hematol Oncol. 2016 Dec 1; 9 (1):134.
3. Saenz DT, et al. Leukemia. 2017 Jan 31. doi: 10.1038/leu.2016.393.

Other Notes

Small volumes of ARV-825 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARV-825 purchase

MBS3602800 is a biochemical targeting ARV-825.
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