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ARV-771

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3603050

ARV-771 is a potent BET degrader (PROTAC) in cellular models of CRPC; potently degrades BRD2/3/4 in 22Rv1 cells with DC50< 5 nM. More details

$290 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
ARV-771, Biochemical
Full Product Name
ARV-771
Product Synonym Names
ARV 771; ARV771
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
986.6398
Suitability
10mM in DMSO
Target
Bromodomain
Receptor
Bromodomain
Chemical Name
(2S, 4R)-1-((2S)-2-(tert-butyl)-15-((6S)-4-(4-chlorophenyl)-2, 3, 9-trimethyl-6H-thieno[3, 2-f][1, 2, 4]triazolo[4, 3-a][1, 4]diazepin-6-yl)-4, 14-dioxo-6, 10-dioxa-3, 13-diazapentadecan-1-oyl)-4-hydroxy-N-((S)-1-(4-(4-methylthiazol-5-yl)phenyl)ethyl)pyrrolidine-2-c
SMILES
CC1=C(C)C(C(C2=CC=C(C)C=C2)=N[C@H]3CC(NCCOCCCOCC(N[C@@H](C(C)(C)C)C(N4[C@H](C(N[C@@H](C)C5=CC=C(C6=C(C)N=CS6)C=C5)=O)C[C@@H](O)C4)=O)=O)=O)=C(S1)N7C3=NN=C7C
Molecular Formula
C49H60ClN9O7S2
CAS Number
1949837-12-0

Product Categories/Family for ARV-771 biochemical

Chromatin/Epigenetic

Structure of ARV-771 biochemical

ARV-771 Biochemical – Cat# MBS3603050

Product References and Citations for ARV-771 biochemical

1. Raina K, et al. Proc Natl Acad Sci U S A. 2016 Jun 28; 113 (26):7124-9.
2. Saenz DT, et al. Leukemia. 2017 Jan 31. doi: 10.1038/leu.2016.393.

Other Notes

Small volumes of ARV-771 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ARV-771 purchase

MBS3603050 is a biochemical targeting ARV-771.
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