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KRM-II-81

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3603139

KRM-II-81 is a potent, selective alpha1/alpha2/alpha3 GABAA receptors positive allosteric modulator with EC50 of 937 nM for alpha1beta3gamma2, negligible efficacy at alpha4/alpha5/alpha6 GABAA receptors. More details

$1100 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
KRM-II-81, Biochemical
Full Product Name
KRM-II-81
Product Synonym Names
KRM-II-81; KRM-II 81; KRM-II81
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
351.369
Target
GAT
Receptor
GAT
Chemical Name
5-(8-ethynyl-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1, 5-a][1, 4]diazepin-3-yl)oxazole
SMILES
C#CC1=CC=C(N2C(CN=C3C4=NC=CC=C4)=C(C5=CN=CO5)N=C2)C3=C1
Molecular Formula
C21H13N5O
CAS Number
2014348-91-3

Product Categories/Family for KRM-II-81 biochemical

Membrane Transporter/Ion Channel

Structure of KRM-II-81 biochemical

KRM-II-81 Biochemical – Cat# MBS3603139

Product References and Citations for KRM-II-81 biochemical

1. Poe MM, et al. J Med Chem. 2016 Dec 8; 59 (23):10800-10806.
2. Lewter LA, et al. ACS Chem Neurosci. 2017 Jun 21; 8 (6):1305-1312.

Other Notes

Small volumes of KRM-II-81 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for KRM-II-81 purchase

MBS3603139 is a biochemical targeting KRM-II-81.
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