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Gefitinib-based PROTAC 3

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3603574

Gefitinib-based PROTAC 3 is a VHL-recruiting PROTAC that induces the degradation of EGFR and EGFR mutants with DC50 of 11.7 nM and 22.3 nM for HCC827 cell (Exon 19 del) and H3255 cell (L858R). More details

$220 / 2 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Gefitinib-based PROTAC 3, Biochemical
Full Product Name
Gefitinib-based PROTAC 3
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
934.522
Suitability
DMSO: >=60mg/mL64.20mM)
Target
PROTAC
Receptor
PROTAC
Chemical Name
(2S, 4R)-1-((S)-2-(3-(2-((5-((4-((3-chloro-4-fluorophenyl)amino)-7-methoxyquinazolin-6-yl)oxy)pentyl)oxy)ethoxy)propanamido)-3, 3-dimethylbutanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide
SMILES
CC1=C(SC=N1)C2=CC=C(C=C2)CNC(=O)C3CC(CN3C(=O)C(C(C)(C)C)NC(=O)CCOCCOCCCCCOC4=C(C=C5C(=C4)C(=NC=N5)NC6=CC(=C(C=C6)F)Cl)OC)O
Molecular Formula
C47H57ClFN7O8S
CAS Number
2230821-27-7

Product Categories/Family for Gefitinib-based PROTAC 3 biochemical

PROTACs

Structure of Gefitinib-based PROTAC 3 biochemical

Gefitinib-Based PROTAC 3 Biochemical – Cat# MBS3603574

Product References and Citations for Gefitinib-based PROTAC 3 biochemical

1. Burslem GM, et al. Cell Chem Biol. 2018 Jan 18; 25 (1):67-77.e3.

Other Notes

Small volumes of Gefitinib-based PROTAC 3 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Gefitinib-based PROTAC 3 purchase

MBS3603574 is a biochemical targeting Gefitinib-based PROTAC 3.
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