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MK-0448

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3606358

MK-0448 is a potent, specific I(Kur) current/Kv1.5 channel inhibitor with IC50 of 8.6 nM, potently inhibits IKur in human atrial myocytes with IC50 of 10.8 nM. More details

$730 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MK-0448, Biochemical
Full Product Name
MK-0448
Product Synonym Names
MK0448
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
448.516
Target
Potassium Channel
Receptor
Potassium Channel
Chemical Name
N-{6-[(1S)-1-(4-fluorophenyl)-2, 2-di(pyridin-3-yl)ethyl]pyridin-2-yl}methanesulfon- amide
SMILES
CS(=O)(NC1=NC([C@H](C2=CC=C(F)C=C2)C(C3=CC=CN=C3)C4=CC=CN=C4)=CC=C1)=O
Molecular Formula
C24H21FN4O2S
CAS Number
875562-81-5

Product Categories/Family for MK-0448 biochemical

Heart Arrhythmia; Cell Cycle/DNA Damage; Cardiovascular Disease

Structure of MK-0448 biochemical

Mk-0448 Biochemical – Cat# MBS3606358

Product References and Citations for MK-0448 biochemical

1. Pavri BB, et al. Circ Arrhythm Electrophysiol. 2012 Dec; 5 (6):1193-201.
2. Loose S, et al. Front Pharmacol. 2014 Mar 4; 5:26.
3. Wolkenberg SE, et al. Bioorg Med Chem Lett. 2017 Feb 15; 27 (4):1062-1069.

Other Notes

Small volumes of MK-0448 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MK-0448 purchase

MBS3606358 is a biochemical targeting MK-0448.
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