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Cortistatin A

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3606395

A potent and selective inhibitor of mediator-associated kinase CDK8 (IC50=12 nM) and its paralogue CDK19. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
Cortistatin A, Biochemical
Full Product Name
Cortistatin A
Product Synonym Names
(+)-cortistatin A
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
472.629
Target
CDK
Receptor
CDK
Chemical Name
(3S, 3aR, 7R, 8R, 9S, 10aR, 12aS, 12bR)-9-(Dimethylamino)-1, 2, 3, 3a, 4, 7, 8, 9, 10, 11, 12, 12b-dodecahydro-3-(7-isoquinolinyl)-3a-methyl-10a, 12a-epoxybenzo[4, 5]cyclohept[1, 2-e]indene-7, 8-diol
SMILES
C[C@@]12[C@@H](C3=CC4=C(C=C3)C=CN=C4)CC[C@@]1([H])[C@@]56CC[C@@]7(O6)C[C@H](N(C)C)[C@@H](O)[C@H](O)C7=CC5=CC2
Molecular Formula
C30H36N2O3
CAS Number
882976-95-6

Product Categories/Family for Cortistatin A biochemical

Angiogenesis

Structure of Cortistatin A biochemical

Cortistatin A Biochemical – Cat# MBS3606395

Product References and Citations for Cortistatin A biochemical

1. Johannessen L, et al. Nat Chem Biol. 2017 Oct; 13 (10):1102-1108.
2. Cee VJ, et al. Angew Chem Int Ed Engl. 2009; 48 (47):8952-7.
3. Poss ZC, et al. Cell Rep. 2016 Apr 12; 15 (2):436-50.
4. Pelish HE, et al. Nature. 2015 Oct 8; 526 (7572):273-276.

Other Notes

Small volumes of Cortistatin A biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cortistatin A purchase

MBS3606395 is a biochemical targeting Cortistatin A.
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