MLN-4924 (Pevonedistat)

Name: MLN-4924 (Pevonedistat); MyBioSource
Brand: MyBioSource
SKU: MBS3606503
Price: 250 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3606503

An analog of adenosine 5’-monophosphate that potently and selectively inhibits NEDD8-activating enzyme (NAE) with IC50 of 4.7 nM. More details

$250 / 2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

MLN-4924, Biochemical

Full Product Name

MLN-4924

Product Synonym Names

Pevonedistat; TAK-924

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

443.5193

Suitability

DMSO: >=111.25mg/mL

Target

NEDD8

Receptor

NAE

Chemical Name

Sulfamic acid, [(1S, 2S, 4R)-4-[4-[[(1S)-2, 3-dihydro-1H-inden-1-yl]amino]-7H-pyrrolo[2, 3-d]pyrimidin-7-yl]-2-hydroxycyclopentyl]methyl ester

SMILES

C1CC2=CC=CC=C2[C@H]1NC3=NC=NC4=C3C=CN4[C@@H]5C[C@H]([C@H](C5)O)COS(=O)(=O)N

Molecular Formula

C21H25N5O4S

CAS Number

905579-51-3

Product Categories/Family for MLN-4924 biochemical

Blood cancer; Proteasome/Ubiquitin; Cancer

Product References and Citations for MLN-4924 biochemical

1. Soucy TA, et al. Nature. 2009 Apr 9; 458 (7239):732-6.
2. Milhollen MA, et al. Blood. 2010 Sep 2; 116 (9):1515-23.
3. Brownell JE, et al. Mol Cell. 2010 Jan 15; 37 (1):102-11.

Other Notes

Small volumes of MLN-4924 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MLN-4924 purchase

MBS3606503 is a biochemical targeting MLN-4924.