RAF265 (CHIR-265)

Name: RAF265 (CHIR-265); MyBioSource
Brand: MyBioSource
SKU: MBS3606638
Price: 240 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3606638

A potent, oral, dual Raf/VEGFR-2 inhibitor with IC50 of 3-60 nM for C-Raf/B-Raf/B-Raf V600E, EC50 of 30 nM for VEGFR2 phosphorylation. More details

$240 / 2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RAF265, Biochemical

Full Product Name

RAF265

Product Synonym Names

CHIR-265; RAF 265; RAF-265; CHIR265

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

518.4139

Suitability

DMSO: >=26mg/mL

Target

Raf

Receptor

B-Raf; VEGFR2

Chemical Name

1H-Benzimidazol-2-amine, 1-methyl-5-[[2-[5-(trifluoromethyl)-1H-imidazol-2-yl]-4-pyridinyl]oxy]-N-[4-(trifluoromethyl)phenyl]

SMILES

FC(F)(C1=CN=C(N1)C2=NC=CC(OC3=CC=C4N(C(NC5=CC=C(C(F)(F)F)C=C5)=NC4=C3)C)=C2)F

Molecular Formula

C24H16F6N6O

CAS Number

927880-90-8

Product Categories/Family for RAF265 biochemical

Skin Cancer; MAPK/ERK Signaling; Cancer

Product References and Citations for RAF265 biochemical

1. Mordant P, et al. Mol Cancer Ther. 2010 Feb; 9 (2):358-68.
2. Zitzmann K, et al. Endocr Relat Cancer. 2011 Mar 21; 18 (2):277-85.
3. Su Y, et al. Clin Cancer Res. 2012 Apr 15; 18 (8):2184-98.
4. Chen J, et al.Cancer Res. 2011 Jun 15; 71 (12):4280-91.

Other Notes

Small volumes of RAF265 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RAF265 purchase

MBS3606638 is a biochemical targeting RAF265.