Cobimetinib (GDC-0973)

Name: Cobimetinib (GDC-0973); MyBioSource
Brand: MyBioSource
SKU: MBS3606676
Price: 235 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3606676

Cobimetinib (GDC-0973, XL-518) is a potent, selective MEK inhibitor with IC50 of 4.2 nM for MEK1. More details

$235 / 2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

Cobimetinib, Biochemical

Full Product Name

Cobimetinib

Product Synonym Names

GDC-0973; XL-518; GDC 0973; XL 518; GDC0973; XL518

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

531.31

Suitability

10mM in DMSO

Target

MEK

Receptor

MEK1

Chemical Name

Methanone, [3, 4-difluoro-2-[(2-fluoro-4-iodophenyl)amino]phenyl][3-hydroxy-3-[(2S)-2-piperidinyl]-1-azetidinyl]

SMILES

C1CCN[C@@H](C1)C2(CN(C2)C(=O)C3=C(C(=C(C=C3)F)F)NC4=C(C=C(C=C4)I)F)O

Molecular Formula

C21H21F3IN3O2

CAS Number

934660-93-2

Product Categories/Family for Cobimetinib biochemical

Skin Cancer; MAPK/ERK Signaling; Cancer

Product References and Citations for Cobimetinib biochemical

1. Hoeflich KP, et al. Cancer Res. 2012 Jan 1; 72 (1):210-9.
2. Wong H, et al. Clin Cancer Res. 2012 Jun 1; 18 (11):3090-9.
3. Rice KD, et al. ACS Med Chem Lett. 2012 Apr 9; 3 (5):416-21.
4. Ribas A, et al. Lancet Oncol. 2014 Aug; 15 (9):954-65.

Other Notes

Small volumes of Cobimetinib biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for Cobimetinib purchase

MBS3606676 is a biochemical targeting Cobimetinib.