Ro-5126766 (CH-5126766)

Name: Ro-5126766 (CH-5126766); MyBioSource
Brand: MyBioSource
SKU: MBS3606775
Price: 255 USD
Availability: InStock
Rating: 5 (10 reviews)

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3606775

A potent, first-in-class dual Raf/MEK inhibitor with IC50 of 56 nM/160 nM for C-Raf/MEK1. More details

$255 / 2 mg +1 FREE 8GB USB

Product Documentation

Sample Manual Insert View PDF

Testing Data View PDF

Certificate of Analysis (COA) View PDF

QC Report View PDF

Material Safety Data Sheet View PDF

Technical Datasheet View PDF

Protocol View PDF

Product Overview

Online Datasheet in PDF

Product Name

RO-5126766, Biochemical

Full Product Name

RO-5126766

Product Synonym Names

CH-5126766

Purity/Purification

>98% (HPLC)

Preparation and Storage

Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack

Molecular Weight

471.4615

Suitability

10mM in DMSO

Target

MEK

Receptor

MEK1; B-Raf; B-Raf (V600E); C-Raf

Chemical Name

Sulfamide, N-[3-fluoro-4-[[4-methyl-2-oxo-7-(2-pyrimidinyloxy)-2H-1-benzopyran-3-yl]methyl]-2-pyridinyl]-N'-methyl

SMILES

CC1=C(C(=O)OC2=C1C=CC(=C2)OC3=NC=CC=N3)CC4=C(C(=NC=C4)NS(=O)(=O)NC)F

Molecular Formula

C21H18FN5O5S

CAS Number

946128-88-7

Product Categories/Family for RO-5126766 biochemical

Solid Tumors; MAPK/ERK Signaling; Cancer

Product References and Citations for RO-5126766 biochemical

1. Aoki T, et al. ACS Med Chem Lett. 2014 Jan 22; 5 (4):309-14.
2. Ishii N, et al. Cancer Res. 2013 Jul 1; 73 (13):4050-60.
3. Wada M, et al. PLoS One. 2014 Nov 25; 9 (11):e113217.

Other Notes

Small volumes of RO-5126766 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RO-5126766 purchase

MBS3606775 is a biochemical targeting RO-5126766.