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LDE225

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3606823

LDE225 (NVP-LDE225; Erismodegib) is a Smoothened (Smo) antagonist, inhibiting Hedgehog (Hh) signaling with IC50 of 1.3 nM (mouse) and 2.5 nM (human), respectively. More details

$240 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
LDE225, Biochemical
Full Product Name
LDE225
Product Synonym Names
NVP-LDE225, Erismodegib
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
485.5
Suitability
Ethanol: 97mg/mL (199.79mM)
DMSO: 97mg/mL (199.79mM)
Target
Hedgehog (Hh)
Receptor
Smoothened; Smoothened
SMILES
C[C@@H]1CN(C[C@@H](O1)C)C2=NC=C(C=C2)NC(=O)C3=CC=CC(=C3C)C4=CC=C(C=C4)OC(F)(F)F
Molecular Formula
C26H26F3N3O3
CAS Number
956697-53-3

Product Categories/Family for LDE225 biochemical

GPCR/G Protein; Cancer

Structure of LDE225 biochemical

LDE225 Biochemical – Cat# MBS3606823

Product References and Citations for LDE225 biochemical

1.Fendrich V, et al. Ann Surg, 2011, 254 (5), 818-23.

Other Notes

Small volumes of LDE225 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for LDE225 purchase

MBS3606823 is a biochemical targeting LDE225.
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