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RO 46-8443

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3607368

RO 46-8443 is the first non-peptide endothelin ETB receptor selective antagonist. RO 46-8443 displays up to 2000-fold selectivity for ETB receptors both in terms of binding inhibitory potency and functional inhibition. More details

$235 / 2 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
RO 46-8443, Biochemical
Full Product Name
RO 46-8443
Product Synonym Names
RO 46-8443; RO46-8443; RO-46-8443; RO 468443
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
609.69
Target
EGFR
Receptor
ET-B
Chemical Name
4-(tert-butyl)-N-(6-(2, 3-dihydroxypropoxy)-5-(2-methoxyphenoxy)-2-(4-methoxyphenyl)pyrimidin-4-yl)benzenesulfonamide
SMILES
c1(ccc(cc1)C(C)(C)C)S(=O)(=O)Nc1nc(nc(c1Oc1c(cccc1)OC)OC[C@@H](CO)O)c1ccc(cc1)OC
Molecular Formula
C31H35N3O8S
CAS Number
175556-12-4

Product Categories/Family for RO 46-8443 biochemical

Angiogenesis

Structure of RO 46-8443 biochemical

Ro 46-8443 Biochemical – Cat# MBS3607368

Product References and Citations for RO 46-8443 biochemical

1.Guimares CL, Trentin PG, Rae GA. Endothelin ET (B) receptor-mediated mechanisms involved in oleic acid-induced acute lung injury in mice. Clin Sci (Lond). 2002 Aug; 103 Suppl 48:340S-344S.

Other Notes

Small volumes of RO 46-8443 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for RO 46-8443 purchase

MBS3607368 is a biochemical targeting RO 46-8443.
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