Structure Specific Recognition Protein 1 (SSRP1) ELISA Kit for Monkey

Function: Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. Binds specifically to single-stranded DNA and RNA with highest affinity for nucleotides G and U. The FACT complex is required for expression of Hox genes. Ref.6

Subunit structure: Component of the FACT complex, a stable heterodimer of dre4/spt16 and Ssrp. Interacts with CHD1 and TRL/GAGA. Ref.6 Ref.7

Subcellular location: Nucleus. Chromosome. Note: Colocalizes with RNA polymerase II on chromatin. Recruited to actively transcribed loci. Ref.7 Ref.8

Tissue specificity: Expressed at highest levels in nurse cells of the ovary.

Developmental stage: Abundant throughout oogenesis and embryogenesis, decreases during larval stages and increases again in pupae.

Sequence similarities: Belongs to the SSRP1 family.Contains 1 HMG box DNA-binding domain.