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L-685, 458

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3608373

L-685, 458 is a specific and potent inhibitor of A beta PP gamma-secretase activity with Ki of 17 nM. More details

$455 / 5 mg +1 FREE 8GB USB
Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
L-685, 458, Biochemical
Full Product Name
L-685, 458
Product Synonym Names
L685458; L-685458; L 685458
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
672.85
Suitability
DMSO: >=31mg/mL (46.07mM)
Target
Other Targets
Receptor
gamma secretase
Chemical Name
tert-butyl((2S, 3R, 5R)-6-(((S)-1-(((S)-1-amino-1-oxo-3-phenylpropan-2-yl)amino)-4-methyl-1-oxopentan-2-yl)amino)-5-benzyl-3-hydroxy-6-oxo-1-phenylhexan-2-yl)carbamate.
SMILES
CC(C)C[C@H](NC(=O)[C@@H](C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)OC(C)(C)C)Cc1ccccc1)C(=O)N[C@@H](Cc1ccccc1)C(N)=O
Molecular Formula
C39H52N4O6
CAS Number
292632-98-5

Product Categories/Family for L-685, 458 biochemical

Neurological Disease

Structure of L-685, 458 biochemical

L-685, 458 Biochemical – Cat# MBS3608373

Product References and Citations for L-685, 458 biochemical

1.Shearman M S, Beher D, Clarke E E, et al. L-685, 458, an aspartyl protease transition state mimic, is a potent inhibitor of amyloid beta-protein precursor gamma-secretase activity [J]. Biochemistry, 2000, 39 (30): 8698-8704.

Other Notes

Small volumes of L-685, 458 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for L-685, 458 purchase

MBS3608373 is a biochemical targeting L-685, 458.
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