JMV 2959

JMV 2959 is a growth hormone secretagogue receptor type 1a (GHS-R1a) antagonist with an IC50 of 32 nM.

1. Moulin A et al. The 124-triazole as a scaffold for the design of ghrelin receptor ligands: development of JMV 2959 a potent antagonist. Amino Acids. 2013 Feb; 44 (2):301-14.
2. Engel JA et al. Blockade of growth hormone secretagogue receptor 1A signaling by JMV 2959 attenuates thenMDAR antagonist phencyclidine-induced impairments in prepulse inhibition. Psychopharmacology (Berl). 2015 Dec; 232 (23):4285-92.
3. Clifford PS et al. Attenuation of cocaine-induced locomotor sensitization in rats sustaining genetic or pharmacologic antagonism of ghrelin receptors. Addict Biol. 2012 Nov; 17 (6):956-63.

Small volumes of JMV 2959 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

MBS3609373 is a biochemical targeting JMV 2959.