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MRTX849

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS3611627

MRTX849 is a potent selective and covalent KRASG12C inhibitor with potential antineoplastic activity.selectively modifies mutant cysteine 12 in GDP-bound KRASG12C and inhibits KRAS-dependent signaling. More details

$240 / 5 mg +1 FREE 8GB USB
Product Documentation
PDF
Sample Manual Insert View PDF
PDF
Testing Data View PDF
PDF
Certificate of Analysis (COA) View PDF
PDF
QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
MRTX849, Biochemical
Full Product Name
MRTX849
Purity/Purification
>98% (HPLC)
Preparation and Storage
Store at -20 degree C
Stability: >=2 years
Shipping: Ice Pack
Molecular Weight
604.12
Suitability
DMSO: 100mg/mL (165.53mM) Need ultrasonic
Target
Ras
Receptor
KRAS G12C
SMILES
CN1CCC[C@H]1COc1nc2CN(CCc2c(n1)N1CCN([C@@H](CC#N)C1)C(=O)C(F)=C)c1cccc2cccc(Cl)c12
Molecular Formula
C32H35ClFN7O2
CAS Number
2326521-71-3

Product Categories/Family for MRTX849 biochemical

MAPK/ERK Signaling; cancer

Structure of MRTX849 biochemical

MRTX849 Biochemical – Cat# MBS3611627

Product References and Citations for MRTX849 biochemical

1.Jill Hallin Lars D Engstrom Lauren Hargis.The KRAS G12C Inhibitor MRTX849 Provides Insight Toward Therapeutic Susceptibility of KRAS-Mutant Cancers in Mouse Models and Patients.Cancer Discov. 2020 Jan; 10 (1):54-71.

Other Notes

Small volumes of MRTX849 biochemical vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MRTX849 purchase

MBS3611627 is a biochemical targeting MRTX849.
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