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A Disintegrin Like and Metalloproteinase with Thrombospondin Type 1 Motif 4 (ADAMTS4) ELISA Kit for Mouse

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS036974

Background/Introduction: This Quantitative Sandwich ELISA kit is only for in vitro research use only! This kit is intended to be used for determination the level of ADAMTS4 (hereafter termed "analyte") in undiluted original Mouse body fluids, tissue… More details

$675 / 48-Strip-Wells +1 FREE 8GB USB

Product Documentation

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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Online Datasheet in PDF
Product Name
A Disintegrin Like and Metalloproteinase With Thrombospondin Type 1 Motif 4 (ADAMTS4), ELISA Kit
Full Product Name
Mouse A Disintegrin Like and Metalloproteinase With Thrombospondin Type 1 Motif 4 ELISA Kit
Product Gene Name
ADAMTS4 elisa kit
Species Reactivity
Mouse
Assay Type
Sandwich
Samples
Undiluted original Mouse body fluids, tissue homogenates, secretions or feces samples. This kit is NOT suitable for assaying non-biological sources of substances.
Detection Range
6.25 ng/ml - 200 ng/ml.
Sensitivity
1.0 ng/ml.
Specificity
No significant cross-reactivity or interference between this analyte and analogues is observed.
Preparation and Storage
Store all reagents at 2-8 degree C
Inter-assay Precision
Inter-assay CV (%) is less than 15%. [CV(%) = SD/mean ×100].
Intra-assay Precision
Intra-assay CV (%) is less than 15%.
Molecular Weight
90,197 Da
Chromosome Location
Chromosome: 1; NC_000001.10 (161159538..161168845, complement). Location: 1q21-q23
OMIM
603876
3D Structure
ModBase 3D Structure for O75173

Other Notes

Small volumes of ADAMTS4 elisa kit vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for ADAMTS4 purchase

MBS036974 is a ready-to-use microwell, strip plate ELISA (enzyme-linked immunosorbent assay) Kit for analyzing the presence of the A Disintegrin Like and Metalloproteinase With Thrombospondin Type 1 Motif 4 (ADAMTS4) ELISA Kit target analytes in biological samples. The concentration gradients of the kit standards or positive controls render a theoretical kit detection range in biological research samples containing ADAMTS4. The ELISA analytical biochemical technique of the MBS036974 kit is based on ADAMTS4 antibody-ADAMTS4 antigen interactions (immunosorbency) and an HRP colorimetric detection system to detect ADAMTS4 antigen targets in samples. The ELISA Kit is designed to detect native, not recombinant, ADAMTS4. Appropriate sample types may include undiluted body fluids and/or tissue homogenates, secretions. Quality control assays assessing reproducibility identified the intra-assay CV (%) and inter-assay CV(%).

Additional Details

NCBI/Uniprot data below describe general gene information for ADAMTS4. It may not necessarily be applicable to this product.

NCBI GI #
157427675
NCBI GeneID
9507
NCBI Accession #
NP_005090.3
UniProt Primary Accession #
O75173
UniProt Secondary Accession #
Q5VTW2; Q6P4Q8; Q6UWA8; Q9UN83
UniProt Related Accession #
O75173
GenBank Nucleotide #
NM_005099.4
NCBI Official Full Name
A disintegrin and metalloproteinase with thrombospondin motifs 4 preproprotein
NCBI Official Synonym Full Names
ADAM metallopeptidase with thrombospondin type 1 motif, 4
NCBI Official Symbol
ADAMTS4
NCBI Official Synonym Symbols
ADMP-1; ADAMTS-2; ADAMTS-4
UniProt Protein Name
A disintegrin and metalloproteinase with thrombospondin motifs 4
UniProt Synonym Protein Names
ADMP-1; Aggrecanase-1
Protein Family
A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name
ADAMTS4
UniProt Synonym Gene Names
KIAA0688; ADAM-TS 4; ADAM-TS4; ADAMTS-4
UniProt Entry Name
ATS4_HUMAN
NCBI Protein Information
A disintegrin and metalloproteinase with thrombospondin motifs 4; ADAM-TS4; ADAM-TS 4; aggrecanase-1; a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 4

NCBI Summary for ADAMTS4

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
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UniProt Comments for ADAMTS4

ADAMTS4: Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.

Protein type: Motility/polarity/chemotaxis; Secreted; Protease; Secreted, signal peptide; EC 3.4.24.82

Chromosomal Location of Human Ortholog: 1q21-q23

Cellular Component: extracellular matrix; proteinaceous extracellular matrix; extracellular space; extracellular region

Molecular Function: peptidase activity; protein binding; protease binding; zinc ion binding; metallopeptidase activity; metalloendopeptidase activity

Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; defense response to bacterium; proteolysis; skeletal development
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Research Articles on ADAMTS4

1. AMTS4 has roles in melanoma growth and angiogenesis

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with ADAMTS4 elisa kit

 Reference Product  PubMed Publications
 ACAN elisa kit  >6 publications with ADAMTS4 and ACAN
 BCAN elisa kit  >3 publications with ADAMTS4 and BCAN
 TGFB1 elisa kit  >3 publications with ADAMTS4 and TGFB1
 FURIN elisa kit  >3 publications with ADAMTS4 and FURIN
 OSM elisa kit  >2 publications with ADAMTS4 and OSM
 IL1B elisa kit  >2 publications with ADAMTS4 and IL1B
 IL17A elisa kit  >1 publications with ADAMTS4 and IL17A
 SRPX2 elisa kit  >1 publications with ADAMTS4 and SRPX2

Pathways associated with ADAMTS4 elisa kit

 Products by Pathway  Pathway Diagram
 Endochondral Ossification Pathway antibodies  Endochondral Ossification Pathway Diagram

Diseases associated with ADAMTS4 elisa kit

 Disease Name  Pubmed Publications
 Inflammation Antibodies  >16 publications with ADAMTS4 and Inflammation
 Neoplasms Antibodies  >14 publications with ADAMTS4 and Neoplasms
 Necrosis Antibodies  >14 publications with ADAMTS4 and Necrosis
 Arthritis, Rheumatoid Antibodies  >7 publications with ADAMTS4 and Arthritis, Rheumatoid
 Nervous System Diseases Antibodies  >5 publications with ADAMTS4 and Nervous System Diseases
 Atherosclerosis Antibodies  >5 publications with ADAMTS4 and Atherosclerosis
 Brain Diseases Antibodies  >5 publications with ADAMTS4 and Brain Diseases
 Heart Diseases Antibodies  >4 publications with ADAMTS4 and Heart Diseases
 Myocardial Infarction Antibodies  >4 publications with ADAMTS4 and Myocardial Infarction
 Carcinoma, Squamous Cell Antibodies  >2 publications with ADAMTS4 and Carcinoma, Squamous Cell

Organs/Tissues associated with ADAMTS4 elisa kit

 Organ/Tissue Name  Pubmed Publications
 Brain Antibodies  >13 publications with ADAMTS4 and Brain
 Muscle Antibodies  >4 publications with ADAMTS4 and Muscle
 Embryonic Tissue Antibodies  >3 publications with ADAMTS4 and Embryonic Tissue
 Lung Antibodies  >1 publications with ADAMTS4 and Lung
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