Cytokeratin HMW 34be12 Antibody – Mouse Monoclonal

Cytokeratin 34betaE12 is a High Molecular Weight cytokeratin that reacts with all squamous and ductal epithelium and stains carcinomas. This antibody recognizes cytokeratins 1, 5, 10, and 14 that are found in complex epithe-lia. Cytokeratin 34betaE12 shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules or endometrial glands; there has been no reactivity with cells derived from simple epithelia. Nerve cells, glial cells and mesenchymal tissue such as blood vessels containing only non-keratin types of intermediate filaments are not labelled; however, reactivity with smooth-muscle cells has been occasionally observed. Mesenchymal Tumors, Lymphomas, Melanomas, Neural Tumors and Neuroendocrine Tumors are unreactive with this antibody. Cytokeratin 34betaE12 has been shown to be useful in distinguishing Prostatic Adenocarcinoma from Hyperplasia of the Prostate.

Small volumes of anti-Cytokeratin HMW 34BE12 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Cellular velcro - that's an accurate description of the complex protein - proteins interactions required to maintain cell contact and tissue integrity. Keratin KCNK and in particular, cytokeratin high molecular weight represents an important link in this system. Clinically relevant and difficult to assay by traditional ELISA WB or flow cytometry methods, cytokeratin HMW is best detected by immunohistochemistry (IHC) using a primary mouse IgG1 monoclonal antibody - antibody 34BE12 clone - and retrieval protocols. This cytokeratin HMW antibody is considered #1 in reagents products category over rabbit polyclonal primary antibodies based on it's pan species human mouse rat cross reactivity. Other advantages include use of a wide range of anti mouse secondary antibodies with ALEXA 174 fluor or AMP labeling, premade IHC IHC kits for rapid performance of complex retrieval and easy to perform protein labeling kits usage to design your own detection system. Submit your ideas for this product.