Thyroglobulin (TG) Antibody – Mouse Monoclonal

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq]

Function: Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3).

Subunit structure: Homodimer.

Subcellular location: Secreted.

Tissue specificity: Thyroid gland specific.

Post-translational modification: Sulfated tyrosines are desulfated during iodination.

Involvement in disease: Defects in TG are the cause of congenital hypothyroidism due to dyshormonogenesis type 3 (CHDH3) [

MIM:274700]. A disorder due to thyroid dyshormonogenesis, causing large goiters of elastic and soft consistency in the majority of patients. Although the degree of thyroid dysfunction varies considerably among patients with defective thyroglobulin synthesis, patients usually have a relatively high serum free triiodothyronine (T3) concentration with disproportionately low free tetraiodothyronine (T4) level. The maintenance of relatively high free T3 levels prevents profound tissue hypothyroidism except in brain and pituitary, which are dependent on T4 supply, resulting in neurologic and intellectual defects in some cases. Ref.20 Ref.22 Ref.23 Ref.24 Ref.25Variations in TG are associated with susceptibility to autoimmune thyroid disease type 3 (AITD3) [

MIM:608175]. AITDs including Graves disease (GD) and Hashimoto thyroiditis (HT), are among the most common human autoimmune diseases. They are complex diseases, which are caused by an interaction between susceptibility genes and nongenetic factors, such as infection. Ref.21

Sequence similarities: Belongs to the type-B carboxylesterase/lipase family.Contains 11 thyroglobulin type-1 domains.