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MUC6 Antibody – Mouse Monoclonal

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS370148

Mucin 6, also known as MUC6, is a human gene. Mucin is a high M.W. (>1,000 kDa) glycoprotein, expressed by mucous cells of the gastric epithelium and by goblet cells of the fetal, precancerous and cancerous colon, but not by those of the normal colon. It also… More details

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Product Overview

Online Datasheet in PDF
Product Name
MUC6, Monoclonal Antibody
Full Product Name
MUC6
Product Gene Name
anti-MUC6 antibody
Clonality
Monoclonal
Isotype
IgG1
Clone Number
CLH5
Host
Mouse
Species Reactivity
Human
Form/Format
Anti-MUC6 is a mouse monoclonal antibody derived from cell culture supernatant that is concentrated, dialyzed, filter sterilized and diluted in buffer pH 7.5, containing BSA and sodium azide as a preservative.
Preparation and Storage
Store at 2 to 8 degree C in the dark.
Molecular Weight
257,051 Da
Chromosome Location
Chromosome: 11; NC_000011.9 (1012824..1036706, complement). Location: 11p15.5
OMIM
158374
3D Structure
ModBase 3D Structure for Q6W4X9
Control
Stomach
Localization
Cytoplasmic
Reactivity Note
Paraffin, Frozen
ISO Certification
Manufactured in an ISO 13485:2016 Certified Laboratory.

Dilution Information of anti-MUC6 antibody

Mouse Anti-MUC6 Monoclonal Antibody – Cat# MBS370148

Immunohistochemistry (IHC) of anti-MUC6 antibody

Mouse Anti-MUC6 Monoclonal Antibody, Immunohistochemistry (IHC) – Cat# MBS370148

Other Notes

Small volumes of anti-MUC6 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Searchable Terms for MUC6 purchase

MBS370148 is an antibody targeting MUC6. Reactive in Human. Host: Mouse.

Additional Details

NCBI/Uniprot data below describe general gene information for MUC6. It may not necessarily be applicable to this product.

NCBI GI #
151301154
NCBI GeneID
4588
NCBI Accession #
NP_005952.2
UniProt Primary Accession #
Q6W4X9
UniProt Secondary Accession #
O15329; Q14394; Q2TUQ5; Q4L207; Q8N8I1; Q8NAK1
UniProt Related Accession #
Q4L213; Q6W3D1; Q6W4X9
GenBank Nucleotide #
NM_005961.2
NCBI Official Full Name
mucin-6
NCBI Official Synonym Full Names
mucin 6, oligomeric mucus/gel-forming
NCBI Official Symbol
MUC6
NCBI Official Synonym Symbols
MUC-6
UniProt Protein Name
Mucin-6
UniProt Synonym Protein Names
Gastric mucin-6
Protein Family
Mucin
UniProt Gene Name
MUC6
UniProt Entry Name
MUC6_HUMAN
NCBI Protein Information
mucin-6; gastric mucin-6; mucin 6, gastric; OTTHUMP00000228589

NCBI Summary for MUC6

The MUC6 gene encodes gastric mucin, a secreted glycoprotein that plays an essential role in epithelial cytoprotection from acid, proteases, pathogenic microorganisms, and mechanical trauma in the gastrointestinal tract (summary by Toribara et al., 1993 [PubMed 7680650]).[supplied by OMIM]

UniProt Comments for MUC6

Function: May provide a mechanism for modulation of the composition of the protective mucus layer related to acid secretion or the presence of bacteria and noxious agents in the lumen. Play an important role in the cytoprotection of epithelial surfaces and are used as tumor markers in a variety of cancers. May play a role in epithelial organogenesis. Ref.10 Ref.11 Ref.12

Subunit structure: Multimer; disulfide-linked. Ref.8

Subcellular location: Secreted.

Tissue specificity: Expressed in the regenerative zone of gastric antrum, gastric body mucosa and gastric incisura mucosa. Expressed in the deeper mucous glands of gastric antrum. Overexpressed in Helicobacter pylori infected gastric epithelium. Highly expressed in duodenal Brunner's glands, gall bladder, seminal vesicle, pancreatic centroacinar cells and ducts, and periductal glands of the common bile duct. Ref.9 Ref.10 Ref.11 Ref.12 Ref.13

Developmental stage: Early expressed in fetal development and was observed in Brunner's glands and pancreatic ducts at 18-19 weeks and in gastric glands at 20 weeks of gestation. Expressed transiently in the nephrogenic zone of the kidney in the early mid-trimester of development. Detected in the epithelium of ureteric buds at 13 weeks and at lower levels from 17 to 23 weeks of gestation. Ref.10 Ref.11

Induction: Up-regulated by NFKB1. Repressed by mithramycin A which is an inhibitor of binding of transcription factors. Ref.14

Post-translational modification: O-glycosylated. Ref.12

Polymorphism: The number of repeats is highly polymorphic and varies among different alleles. These repeats are very similar but not identical.

Sequence similarities: Contains 1 CTCK (C-terminal cystine knot-like) domain.Contains 1 TIL (trypsin inhibitory-like) domain.Contains 3 VWFD domains.

Sequence caution: The sequence AK092533 differs from that shown. Reason: Erroneous termination at position 2357. Translated as Glu.The sequence BAC04860.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
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Research Articles on MUC6

1. use of MUC6 to differentiate hyperplastic polyps from sessile serrated adenoma/polyps (SSA/P) or SSA/P with dysplasia in individual cases is not reliable because of a lack of specificity.

Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

Products associated with anti-MUC6 antibody

 Reference Product  PubMed Publications
 TFF1 antibody  >21 publications with MUC6 and TFF1

Pathways associated with anti-MUC6 antibody

 Products by Pathway  Pathway Diagram
 Metabolism Of Proteins Pathway antibodies  Metabolism Of Proteins Pathway Diagram
 O-linked Glycosylation Of Mucins Pathway antibodies  O-linked Glycosylation Of Mucins Pathway Diagram
 Post-translational Protein Modification Pathway antibodies  Post-translational Protein Modification Pathway Diagram
 Termination Of O-glycan Biosynthesis Pathway antibodies  Termination Of O-glycan Biosynthesis Pathway Diagram

Diseases associated with anti-MUC6 antibody

 Disease Name  Pubmed Publications
 Breast Neoplasms Antibodies  >22 publications with MUC6 and Breast Neoplasms
 Liver Neoplasms Antibodies  >22 publications with MUC6 and Liver Neoplasms
 Uterine Cervical Neoplasms Antibodies  >9 publications with MUC6 and Uterine Cervical Neoplasms

Organs/Tissues associated with anti-MUC6 antibody

 Organ/Tissue Name  Pubmed Publications
 Stomach Antibodies  >178 publications with MUC6 and Stomach
 Intestine Antibodies  >73 publications with MUC6 and Intestine
 Pancreas Antibodies  >45 publications with MUC6 and Pancreas
 Lung Antibodies  >18 publications with MUC6 and Lung
 Kidney Antibodies  >9 publications with MUC6 and Kidney
 Uterus Antibodies  >8 publications with MUC6 and Uterus
 Prostate Antibodies  >7 publications with MUC6 and Prostate
 Larynx Antibodies  >6 publications with MUC6 and Larynx
 Ascites Antibodies  >2 publications with MUC6 and Ascites
 Mammary Gland Antibodies  >2 publications with MUC6 and Mammary Gland
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