Estrogen Receptor (ESR1) Antibody – Mouse Monoclonal

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

ER-alpha: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described.

Protein type: DNA-binding; Nuclear receptor

Chromosomal Location of Human Ortholog: 6q25.1

Cellular Component: cytoplasm; nuclear chromatin; nucleoplasm; nucleus; plasma membrane

Molecular Function: ATPase binding; beta-catenin binding; chromatin binding; enzyme binding; estrogen response element binding; identical protein binding; protein binding; steroid binding; steroid hormone receptor activity; transcription factor binding

Biological Process: elevation of cytosolic calcium ion concentration; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); negative regulation of I-kappaB kinase/NF-kappaB cascade; negative regulation of transcription factor activity; negative regulation of transcription from RNA polymerase II promoter; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; response to estradiol stimulus; response to estrogen stimulus; signal transduction; steroid hormone receptor signaling pathway; transcription from RNA polymerase II promoter; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent

Disease: Breast Cancer; Estrogen Resistance; Migraine With Or Without Aura, Susceptibility To, 1; Myocardial Infarction, Susceptibility To