HCK Antibody – Rabbit

The protein encoded by this gene is a member of the Src family of tyrosine kinases. This protein is primarily hemopoietic, particularly in cells of the myeloid and B-lymphoid lineages. It may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Multiple isoforms with different subcellular distributions are produced due to both alternative splicing and the use of alternative translation initiation codons, including a non-AUG (CUG) codon. [provided by RefSeq, Feb 2010]

Hck: a protein-tyrosine kinase of the Src family that is predominantly expressed in hemopoietic cell types. The encoded protein may help couple the Fc receptor to the activation of the respiratory burst. In addition, it may play a role in neutrophil migration and in the degranulation of neutrophils. Alternate translation initiation site usage, including a non-AUG (CUG) codon, results in the production of two different isoforms that have different subcellular localization.

Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Kinase, protein; Protein kinase, TK; Oncoprotein; TK group; Src family

Chromosomal Location of Human Ortholog: 20q11-q12

Cellular Component: Golgi apparatus; extrinsic to internal side of plasma membrane; transport vesicle; focal adhesion; cell projection; lysosome; actin filament; caveola; cytosol; nucleus

Molecular Function: protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; ATP binding; receptor binding

Biological Process: respiratory burst after phagocytosis; peptidyl-tyrosine phosphorylation; viral reproduction; protein amino acid autophosphorylation; regulation of phagocytosis; protein amino acid phosphorylation; regulation of cell shape; leukocyte migration during immune response; regulation of transcription factor activity; leukocyte degranulation; positive regulation of cell proliferation; lipopolysaccharide-mediated signaling pathway; mesoderm development; cell differentiation; innate immune response-activating signal transduction; cell adhesion; inflammatory response; integrin-mediated signaling pathway; cytokine and chemokine mediated signaling pathway; regulation of defense response to virus by virus; positive regulation of actin filament polymerization; regulation of inflammatory response; innate immune response; transmembrane receptor protein tyrosine kinase signaling pathway; negative regulation of apoptosis