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OVCA1 Antibody – Rabbit

For Research Use Only. Not for use in diagnostic procedures. Catalog #: MBS375014

MBS375014 is an antibody targeting OVCA1. Also known as Rabbit Anti-OVCA1. Reactive in Human. Host: Rabbit. More details

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Product Documentation
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Sample Manual Insert View PDF
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Testing Data View PDF
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Certificate of Analysis (COA) View PDF
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QC Report View PDF
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Material Safety Data Sheet View PDF
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Technical Datasheet View PDF
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Protocol View PDF

Product Overview

Product Name
OVCA1, Antibody
Full Product Name
Rabbit Anti-OVCA1
Product Gene Name
Product Synonym Names
Candidate tumor suppressor in ovarian cancer 1 antibody; Diphthamide biosynthesis protein 1antibody; Diphthamide biosynthesis protein 2 homolog like 1 antibody; Diphthamide biosynthesis protein 2 likeantibody; Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1antibody; Diptheria toxin resistance protein required for diphthamide biosynthesis like 1 antibody; DPH like 1 (S.cerevisiae) antibody; DPH like 1 antibody; DPH1 antibody; DPH1 homolog (S. cerevisiae) antibody; DPH1 homologantibody; DPH2 like 1 antibody; DPH2L antibody; DPH2L1 antibody; FLJ33211 antibody; HsDph1 antibody; Ovariancancer associated gene 1 antibody; Ovarian cancer associated gene 1 protein antibody; Ovarian tumor suppressorcandidate 1 antibody
Host
Rabbit
Species Reactivity
Human
Form/Format
Antiserum containing PBS 0.1% sodium azide
Purity/Purification
Unpurified
Specificity
This antibody recognises human OVCA1 endogenous protein on A2780 whole cell lysate and OVCAR5 total protein extract.
Molecular Weight
48,004 Da
3D Structure
ModBase 3D Structure for Q5NCQ5
Target Antigen
OVCA1
Immunogen
Synthetic peptide: RGRISRGRLANQ conjugated to KLH, corresponding to amino acids 20-31 of Human OVCA1
Applications Tested/Suitable for anti-OVCA1 antibody
Western Blot (WB)
Application Notes for anti-OVCA1 antibody
Optimal antibody dilution should be determined by titration, however as a guideline try; WB: 1/1000. Predicted molecular weight: 48 kDa

Product References and Citations for anti-OVCA1 antibody

OVCA2 is downregulated and degraded during retinoidinduced apoptosis. Prowse AH (Int J Cancer,May 2002) PUBMED

Other Notes

Small volumes of anti-OVCA1 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.

Additional Details

NCBI/Uniprot data below describe general gene information for OVCA1. It may not necessarily be applicable to this product.

NCBI GI #
NCBI GeneID
NCBI Accession #
UniProt Primary Accession #
UniProt Secondary Accession #
UniProt Related Accession #
NCBI Official Full Name
OVCA1
NCBI Official Synonym Full Names
DPH1 homolog (S. cerevisiae)
NCBI Official Symbol
Dph1
NCBI Official Synonym Symbols
Ovca1; Dph2l1; AW551873; 2310011M22Rik; 4930488F09Rik
UniProt Protein Name
Diphthamide biosynthesis protein 1
UniProt Synonym Protein Names
DPH1 homolog; MmDph1; Diphthamide biosynthesis protein 2 homolog-like 1; DPH2-like 1; Ovarian cancer-associated gene 1 protein homolog
Protein Family
UniProt Gene Name
Dph1
UniProt Synonym Gene Names
Dph2l1; Ovca1; MmDph1; DPH2-like 1
UniProt Entry Name
DPH1_MOUSE
NCBI Protein Information
diphthamide biosynthesis protein 1; DPH2-like 1; diphthamide biosynthesis protein 2 homolog-like 1; diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces)-like 1; mmDph1; ovarian cancer-associated gene 1 protein homolog

UniProt Comments for OVCA1

DPH1: Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2. When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers. Plays a role in embryonic growth, organogenesis and postnatal survival. Belongs to the DPH1/DPH2 family. DPH1 subfamily. 3 isoforms of the human protein are produced by alternative splicing.

Protein type: Tumor suppressor

Cellular Component: cytoplasm; nucleus

Molecular Function: protein binding

Biological Process: cell proliferation; peptidyl-diphthamide biosynthetic process from peptidyl-histidine
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Precautions

All of MyBioSource's Products are for scientific laboratory research purposes and are not for diagnostic, therapeutics, prophylactic or in vivo use. Through your purchase, you expressly represent and warrant to MyBioSource that you will properly test and use any Products purchased from MyBioSource in accordance with industry standards. MyBioSource and its authorized distributors reserve the right to refuse to process any order where we reasonably believe that the intended use will fall outside of our acceptable guidelines.

Disclaimer

While every efforts were made to ensure the accuracy of the information provided in this datasheet, MyBioSource will not be liable for any omissions or errors contained herein. MyBioSource reserves the right to make changes to this datasheet at any time without prior notice.

It is the responsibility of the customer to report product performance issues to MyBioSource within 30 days of receipt of the product. Please visit our Terms & Conditions page for more information.

Product Note

Select online data sheet information is drawn from bioinformatics databases, occasionally resulting in ambiguous or non-relevant product information. It is the responsibility of the customer to review, verify, and evaluate the information to make sure it matches their requirements before purchasing the kit. Our ELISA Kit assays are dynamic research tools and sometimes they may be updated and improved. If the format of this assay is important to you then please request the current manual or contact our technical support team with a presales inquiry before placing an order. We will confirm the current details of the assay. We cannot guarantee the sample manual posted online is the most current manual, it is intended to serve as an example only. Please refer to the instructions For Use provided with the assay kit for precise details.

Product PubMed Publications

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