MUS81 Antibody – Mouse Monoclonal

MBS375160 is an antibody targeting Mus81. Also known as Mouse Anti-Mus81 [MTA30 2G10/3]. Reactive in Human. Host: Mouse.

Inagaki H et al. Two sequential cleavage reactions on cruciform DNA structures cause palindrome-mediated chromosomal translocations.Nat Commun. 2013;4:1592. doi: 10.1038/ncomms2595.WB ; Human PMID: 23481400 Murfuni I et al. Perturbed replication induced genome wide or at common fragile sites is differently managed in the absence of WRN. Carcinogenesis 33:1655-63 (2012) PUBMED Duquette ML et al. CtIP is required to initiate replication-dependent interstrand crosslink repair. PLoS Genet 8:e1003050 (2012). WB, ICC/IF ; Human PUBMED Stoepker C et al. SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet 43:138-41 (2011). IP WB ; Human PMID: 21240277 Dom-nguez-Kelly R et al. Wee1 controls genomic stability during replication by regulating the Mus81-Eme1 endonuclease. J Cell Biol 194:567-79 (2011) PUBMED Regairaz M et al. Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes. J Cell Biol 195:739-49 (2011) PUBMED Rass U et al. Mechanism of Holliday junction resolution by the human GEN1 protein. Genes Dev 24:1559-69 (2010). WB ; Human PUBMED Mu+/-oz IM et al. Coordination of structure-specific nucleases by human SLX4/BTBD12 is required for DNA repair.Mol Cell. 2009 Jul 10;35(1):116-27. doi: 10.1016/j.molcel.2009.06.020.WB ; Human PMID: 19595721 Zeng S et al. Telomere recombination requires the MUS81 endonuclease. Nat Cell Biol 11:616-23 (2009) PUBMED Svendsen JM et al. Mammalian BTBD12/SLX4 assembles a Holliday junction resolvase and is required for DNA repair. Cell 138:63-77 (2009). WB ; Human PUBMED Nomura Y et al. Human Mus81 and FANCB independently contribute to repair of DNA damage during replication.Genes Cells. 2007 Oct;12(10):1111-22.ICC/IF WB ; Human PMID: 17903171 Liu C et al. Increased expression and activity of repair genes TDP1 and XPF in non-small cell lung cancer.Lung Cancer. 2007 Mar;55(3):303-11. Epub 2006 Nov 21.WB ; Human PMID: 17118488 Human Mus81 and FANCB independently contribute to repair of DNA damage during replication. Yuji Nomura et al (Genes to Cells,October 2007)PUBMED Taylor ER & McGowan CH Cleavage mechanism of human Mus81-Eme1 acting on Holliday-junction structures. Proc Natl Acad Sci U S A 105:3757-62 (2008). IP ; Human PUBMED Franchitto A et al. Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway. J Cell Biol 183:241-52 (2008). WB ; Human PUBMED

Small volumes of anti-Mus81 antibody vial(s) may occasionally become entrapped in the seal of the product vial during shipment and storage. If necessary, briefly centrifuge the vial on a tabletop centrifuge to dislodge any liquid in the container`s cap. Certain products may require to ship with dry ice and additional dry ice fee may apply.