PDE2A Antibody – Rabbit

PDE2A: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Belongs to the cyclic nucleotide phosphodiesterase family. PDE2 subfamily. 4 isoforms of the human protein are produced by alternative splicing.

Protein type: Nucleotide Metabolism - purine; Mitochondrial; Phosphodiesterase; EC 3.1.4.17

Cellular Component: Golgi apparatus; endoplasmic reticulum; dendrite; cytosol; lipid raft; presynaptic membrane; membrane; axon; mitochondrial matrix; perinuclear region of cytoplasm; cytoplasm; plasma membrane; intracellular; nucleus

Molecular Function: protein homodimerization activity; phosphoric diester hydrolase activity; TPR domain binding; hydrolase activity; metal ion binding; nucleotide binding; cGMP-stimulated cyclic-nucleotide phosphodiesterase activity; cGMP binding; cyclic-nucleotide phosphodiesterase activity; drug binding; cAMP binding; 3',5'-cyclic-nucleotide phosphodiesterase activity

Biological Process: cGMP-mediated signaling; metabolic process; cAMP catabolic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction; positive regulation of vascular permeability; negative regulation of cAMP biosynthetic process; cAMP-mediated signaling; negative regulation of protein import into nucleus, translocation; negative regulation of vascular permeability; cGMP catabolic process; regulation of cGMP metabolic process; protein targeting to mitochondrion; positive regulation of inflammatory response